Serum cystatin C predicts the risk of non-ST-elevation acute coronary syndrome

被引：0
|
作者：
Dong, Hao [1 ]
Xiao, Dongping [2 ]
Tang, Yong [1 ]
机构：
[1] Nanjing Univ Chinese Med, Hosp Nanjing 2, Dept Cardiol, Nanjing 210000, Peoples R China
[2] First Hosp Nanchang, Dept Cardiol, Nanchang 330000, Peoples R China
来源：
JOURNAL OF CARDIOTHORACIC SURGERY | 2023年 / 18卷 / 01期
关键词：
Non-ST-elevation acute coronary syndrome; Cystatin C; Inflammation; Biomarker; ARTERY-DISEASE; EVENTS;
D O I：
10.1186/s13019-023-02465-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
ObjectiveInflammation markers have been proposed as the predictors of adverse cardiac events in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). This study aimed to investigate prognostic value of serum cystatin C (Cys-C) for NSTE-ACS patients.MethodsCys-C, neutrophil to lymphocyte ratio (NLR) and high-sensitivity C-reactive protein (hsCRP) were examined in 212 NSTE-ACS patients and 60 controls. Global registry of acute coronary events (GRACE) score and major adverse cardiac events (MACE) in NSTE-ACS patients were recorded.ResultsCys-C level in the serum was significantly higher in NSTE-ACS patients than in control, and was positively correlated with hsCRP level and NLR as well as GRACE score at admission and 6 months after discharge in NSTE-ACS patients. Serum Cys-C level was identified as a new predictor of MACE.ConclusionSerum Cys-C level may be an inflammation biomarker in patients with NSTE-ACS, and could be used as an independent predictor of MACE.
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页数：4
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