Local Control Following Stereotactic Body Radiation Therapy for Liver Oligometastases: Lessons from a Quarter Century

被引：2

作者：

Mheid, Sara ^{[1
]}

Allen, Stefan ^{[2
]}

Ng, Sylvia S. W. ^{[3
]}

Hall, William A. ^{[4
]}

Sanford, Nina N. ^{[5
]}

Aguilera, Todd A. ^{[5
]}

Elamir, Ahmed M. ^{[5
]}

Bahij, Rana ^{[6
]}

Intven, Martijn P. W. ^{[7
]}

Radhakrishna, Ganesh ^{[8
]}

Mohamad, Issa ^{[9
]}

De Leon, Jeremy ^{[10
]}

Tan, Hendrick ^{[11
,12
]}

Lewis, Shirley ^{[13
]}

Gani, Cihan ^{[14
]}

Stanecu, Teo ^{[1
]}

Dell'Acqua, Veronica ^{[15
]}

Hosni, Ali ^{[1
]}

机构：

[1] Univ Toronto, Princess Margaret Canc Ctr, Dept Radiat Oncol, Toronto, ON M5G 2M9, Canada

[2] Dalhousie Univ, Dept Radiat Oncol, Nova Scotia Hlth, Halifax, NS B3H 4R2, Canada

[3] Univ Toronto, Odette Canc Ctr, Sunnybrook Hlth Sci Ctr, Dept Radiat Oncol, Toronto, ON M4N 3M5, Canada

[4] Med Coll Wisconsin, Dept Radiat Oncol, Milwaukee, WI 53226 USA

[5] Univ Texas Southwestern, Dept Radiat Oncol, Dallas, TX 75235 USA

[6] Odense Univ Hosp, Dept Oncol, DK-5000 Odense, Denmark

[7] Univ Med Ctr, Dept Radiotherapy, Div Imaging & Oncol, NL-3584 CX Utrecht, Netherlands

[8] Christie NHS Fdn Trust, Dept Radiotherapy, Manchester M20 4BX, England

[9] King Hussein Canc Ctr, Dept Radiat Oncol, Amman 11941, Jordan

[10] GenesisCare, Alexandria, NSW 2015, Australia

[11] Fiona Stanley Hosp, Dept Radiat Oncol, Perth, WA 6150, Australia

[12] GenesisCare, Perth, WA 6150, Australia

[13] Manipal Acad Higher Educ, Kasturba Med Coll, Manipal Comprehens Canc Care Ctr, Dept Radiotherapy & Oncol, Manipal 576104, India

[14] Univ Hosp Tubingen, Dept Radiat Oncol, D-72076 Tubingen, Germany

[15] Linac Based RT, Med Affairs & Clin Res, I-20864 Milan, Lombardy, Italy

来源：

CURRENT ONCOLOGY | 2023年 / 30卷 / 10期

关键词：

liver; SBRT; oligometastases; DOSE-ESCALATION TRIAL; PHASE-I/II TRIAL; RADIOFREQUENCY ABLATION; COLORECTAL-CANCER; MOTION MANAGEMENT; CLINICAL-OUTCOMES; I TRIAL; RADIOTHERAPY; METASTASES; SBRT;

D O I：

10.3390/curroncol30100667

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The utilization of stereotactic body radiation therapy for the treatment of liver metastasis has been widely studied and has demonstrated favorable local control outcomes. However, several predictive factors play a crucial role in the efficacy of stereotactic body radiation therapy, such as the number and size (volume) of metastatic liver lesions, the primary tumor site (histology), molecular biomarkers (e.g., KRAS and TP53 mutation), the use of systemic therapy prior to SBRT, the radiation dose, and the use of advanced technology and organ motion management during SBRT. These prognostic factors need to be considered when clinical trials are designed to evaluate the efficacy of SBRT for liver metastases.

引用

页码：9230 / 9243

页数：14

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