Semi-Synthesis of (+)-Digitoxigenin from Androstenedione

被引：0

作者：

Wei, Linlin ^{[1
]}

Qiao, Kaikai ^{[1
]}

Shi, Lei ^{[1
,1
]}

机构：

[1] Dalian Univ Technol, Dalian 116024, Peoples R China

来源：

SYNLETT | 2023年

基金：

中国国家自然科学基金;

关键词：

cardiotonic steroids; digitoxigenin; androstenedione; Stille cross-coupling; hydroxylation; semi-synthesis; ALPHA; BETA-UNSATURATED CARBONYL-COMPOUNDS; ENANTIOSELECTIVE TOTAL-SYNTHESIS; CARDIAC-GLYCOSIDES; CARDENOLIDE; DIGITOXIGENIN; OXIDATION;

D O I：

10.1055/a-2114-8823

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient stereoselective semi-synthesis of (+)-digitoxigenin has been achieved by a nine-step sequence with a 20.4% overall yield. The key features of the synthesis include a Saegusa-Ito oxidation reaction, a direct C14 beta-hydroxylation, and a Stille cross-coupling.

引用

页数：3

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