Semi-Synthesis of (+)-Digitoxigenin from Androstenedione

被引：0
|
作者：
Wei, Linlin [1 ]
Qiao, Kaikai [1 ]
Shi, Lei [1 ,1 ]
机构：
[1] Dalian Univ Technol, Dalian 116024, Peoples R China
来源：
SYNLETT | 2023年
基金：
中国国家自然科学基金;
关键词：
cardiotonic steroids; digitoxigenin; androstenedione; Stille cross-coupling; hydroxylation; semi-synthesis; ALPHA; BETA-UNSATURATED CARBONYL-COMPOUNDS; ENANTIOSELECTIVE TOTAL-SYNTHESIS; CARDIAC-GLYCOSIDES; CARDENOLIDE; DIGITOXIGENIN; OXIDATION;
D O I：
10.1055/a-2114-8823
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient stereoselective semi-synthesis of (+)-digitoxigenin has been achieved by a nine-step sequence with a 20.4% overall yield. The key features of the synthesis include a Saegusa-Ito oxidation reaction, a direct C14 beta-hydroxylation, and a Stille cross-coupling.
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页数：3
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