Low Rates of Antifungal Therapeutic Drug Monitoring Among Inpatients Who Received Itraconazole, Posaconazole, or Voriconazole, United States, 2019-2021

被引：9

作者：

Benedict, Kaitlin ^{[1
,6
]}

Gold, Jeremy A. W. ^{[1
]}

Toda, Mitsuru ^{[1
]}

Thompson, George R. ^{[2
,3
]}

Wiederhold, Nathan P. ^{[4
]}

Smith, Dallas J. ^{[1
,5
,6
]}

机构：

[1] Ctr Dis Control & Prevent, Mycot Dis Branch, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA

[2] Univ Calif Davis, Davis Med Ctr, Dept Internal Med, Div Infect Dis, Sacramento, CA USA

[3] Univ Calif Davis, Dept Med Microbiol & Immunol, Davis, CA USA

[4] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol & Lab Med, Fungus Testing Lab, San Antonio, TX USA

[5] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA

[6] Ctr Dis Control & Prevent, Mycot Dis Branch, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, 1600 Clifton Rd NE, MS H24-9, Atlanta, GA 30329 USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2023年 / 10卷 / 08期

关键词：

drug monitoring; itraconazole; posaconazole; United States; voriconazole; GUIDELINES; SOCIETY;

D O I：

10.1093/ofid/ofad389

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antifungal therapeutic drug monitoring (TDM) is recommended for hospitalized patients receiving itraconazole, posaconazole, or voriconazole for treatment or prophylaxis. In this analysis of hospital-based data, TDM was uncommonly performed (15.8%) in a large cohort of eligible patients, suggesting missed opportunities to avoid subtherapeutic drug levels and minimize toxicity.

引用

页数：4

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