Global Epidemiology and Burden of Elderly-Onset Inflammatory Bowel Disease: A Decade in Review

被引:14
作者
Danpanichkul, Pojsakorn [1 ]
Suparan, Kanokphong [1 ]
Arayakarnkul, Suchapa [2 ]
Jaroenlapnopparat, Aunchalee [3 ]
Polpichai, Natchaya [4 ]
Fangsaard, Panisara [5 ]
Kongarin, Siwanart [6 ]
Srisurapanont, Karan [6 ]
Sukphutanan, Banthoon [6 ]
Wanchaitanawong, Wasuwit [7 ]
Kanjanakot, Yatawee [8 ]
Pupaibool, Jakrapun [9 ]
Duangsonk, Kwanjit [10 ]
Kochhar, Gursimran Singh [11 ]
Wijarnpreecha, Karn [12 ,13 ]
机构
[1] Chiang Mai Univ, Fac Med, Dept Microbiol, Immunol Unit, Chiang Mai 50200, Thailand
[2] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA
[3] Mt Auburn Hosp, Dept Med, Beth Israel Lahey Hlth, Cambridge, MA 02138 USA
[4] Weiss Mem Hosp, Dept Internal Med, Chicago, IL 60640 USA
[5] Bassett Med Ctr, Dept Internal Med, Cooperstown, NY 13326 USA
[6] Chiang Mai Univ, Fac Med, Chiang Mai 50200, Thailand
[7] Chiang Mai Univ, Fac Med, Dept Internal Med, Div Gastroenterol & Hepatol, Chiang Mai 50200, Thailand
[8] Mae Fah Luang Univ, Sch Med, Dept Surg, Chiang Rai 57100, Thailand
[9] Univ Utah, Dept Internal Med, Div Infect Dis, Salt Lake City, UT 84112 USA
[10] Chiang Mai Univ, Fac Med, Dept Microbiol, Chiang Mai 50200, Thailand
[11] Allegheny Hlth Network, Div Gastroenterol & Hepatol, Pittsburgh, PA 15212 USA
[12] Univ Arizona, Dept Med, Div Gastroenterol & Hepatol, Coll Med, Phoenix, AZ 85004 USA
[13] Banner Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Med Ctr, Phoenix, AZ 85006 USA
关键词
inflammatory bowel disease; Crohn's disease; ulcerative colitis; geriatric; CROHNS-DISEASE; PREVALENCE;
D O I
10.3390/jcm12155142
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Inflammatory bowel disease (IBD), once thought to impact younger individuals, now manifests in approximately 10% of patients over 65, characterized by a heightened vulnerability to complications and greater diagnostic intricacies than conventional cases. However, comprehensive global epidemiological data regarding elderly-onset IBD are currently insufficient. Our study addresses this critical gap by analyzing trends in elderly-onset IBD over a decade, encompassing the estimation of annual frequencies and age-standardized rates of elderly-onset IBD burden for both genders, stratifying the data by geographical and sociodemographic factors. Our research highlights a notable increase in the proportion of elderly-onset IBD, constituting around 13% of all IBD cases. We observed a rising incidence in males, contrasted by a decreasing trend in females. The highest surge in incidence rates was seen in the Western Pacific region in both genders, but the highest burden was observed in America. Countries with high sociodemographic index (SDI) carried the greatest burden of elderly-onset IBD, while countries with low SDI had the least. The mortality and disability-adjusted life years (DALYs) rates trend downward in most regions. This study underscores an increasing incidence and proportion of IBD, particularly in elderly-onset IBD, particularly in males. While mortality and DALYs are decreasing in most regions, the overall burden remains highest in America and high-SDI countries. Effective public health interventions and comprehensive studies are required to tackle this mounting burden.
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页数:11
相关论文
共 23 条
[1]  
Afzali Anita, 2018, Curr Treat Options Gastroenterol, V16, P289, DOI [10.1007/s11938-018-0188-9, 10.1007/s11938-018-0188-9]
[2]   The Rising Burden of Inflammatory Bowel Disease in Denmark Over Two Decades: A Nationwide Cohort Study [J].
Agrawal, Manasi ;
Christensen, Heidi S. ;
Bogsted, Martin ;
Colombel, Jean-Frederic ;
Jess, Tine ;
Allin, Kristine H. .
GASTROENTEROLOGY, 2022, 163 (06) :1547-+
[3]   Inflammatory Bowel Disease in the Elderly Is Associated With Worse Outcomes: A National Study of Hospitalizations [J].
Ananthakrishnan, Ashwin N. ;
McGinley, Emily L. ;
Binion, David G. .
INFLAMMATORY BOWEL DISEASES, 2009, 15 (02) :182-189
[4]  
Benchimol Eric I, 2019, J Can Assoc Gastroenterol, V2, pS1, DOI [10.1093/jcag/gwy052, 10.1093/jcag/gwy052]
[5]   Past and Future Burden of Inflammatory Bowel Diseases Based on Modeling of Population-Based Data [J].
Coward, Stephanie ;
Clement, Fiona ;
Benchimol, Eric I. ;
Bernstein, Charles N. ;
Avina-Zubieta, J. Antonio ;
Bitton, Alain ;
Carroll, Mathew W. ;
Hazlewood, Glen ;
Jacobson, Kevan ;
Jelinski, Susan ;
Deardon, Rob ;
Jones, Jennifer L. ;
Kuenzig, M. Ellen ;
Leddin, Desmond ;
McBrien, Kerry A. ;
Murthy, Sanjay K. ;
Nguyen, Geoffrey C. ;
Otley, Anthony R. ;
Panaccione, Remo ;
Rezaie, Ali ;
Rosenfeld, Greg ;
Pena-Sanchez, Juan Nicolas ;
Singh, Harminder ;
Targownik, Laura E. ;
Kaplan, Gilaad G. .
GASTROENTEROLOGY, 2019, 156 (05) :1345-+
[6]  
del Val JH, 2011, World 5 Gastroenterol, V17, P2739
[7]   Inflammatory bowel disease: clinical aspects and treatments [J].
Fakhoury, Marc ;
Negrulj, Rebecca ;
Mooranian, Armin ;
Al-Salami, Hani .
JOURNAL OF INFLAMMATION RESEARCH, 2014, 7 :113-120
[8]   Inflammatory Bowel Disease Presentation and Diagnosis [J].
Flynn, Sean ;
Eisenstein, Samuel .
SURGICAL CLINICS OF NORTH AMERICA, 2019, 99 (06) :1051-+
[9]  
Geboes K, 2001, ACTA GASTRO-ENT BELG, V64, P197
[10]   Clinical spectrum of elderly-onset inflammatory bowel disease in India [J].
Gupta, Yogesh Kumar ;
Singh, Arshdeep ;
Narang, Vikram ;
Midha, Vandana ;
Mahajan, Ramit ;
Mehta, Varun ;
Singh, Dharmatma ;
Bansal, Namita ;
Durairaj, Madeline Vithya Barnaba ;
Dutta, Amit Kumar ;
Sood, Ajit .
INTESTINAL RESEARCH, 2023, 21 (02) :216-225