Unmasking the Deceptive Nature of Cancer Stem Cells: The Role of CD133 in Revealing Their Secrets

被引：15
作者：
Pospieszna, Julia [1 ]
Dams-Kozlowska, Hanna [2 ,3 ]
Udomsak, Wachirawit [1 ]
Murias, Marek [1 ,4 ]
Kucinska, Malgorzata [1 ]
机构：
[1] Poznan Univ Med Sci, Dept Toxicol, 30 Dojazd St,10 Uniwersytetu Poznanskiego St, PL-60631 Poznan, Poland
[2] Poznan Univ Med Sci, Dept Canc Immunol, 15 Garbary St, PL-61866 Poznan, Poland
[3] Greater Poland Canc Ctr, Dept Diagnost & Canc Immunol, 15 Garbary St, PL-61866 Poznan, Poland
[4] Adam Mickiewicz Univ, Ctr Adv Technol, Uniwersytetu Poznanskiego 10 St, PL-61614 Poznan, Poland
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 13期
基金：
英国科研创新办公室;
关键词：
CD133; prominin-1; cancer stem cells; gene therapy; immunotherapy; nanotechnology; ANTI-CD133; MONOCLONAL-ANTIBODY; TUMOR-INITIATING CELLS; HEMATOPOIETIC STEM; SIGNALING PATHWAY; NEURAL STEM; LITHOCARPUS-POLYSTACHYUS; GOLD NANOPARTICLES; PROGENITOR CELLS; POOR-PROGNOSIS; GENE-TRANSFER;
D O I：
10.3390/ijms241310910
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer remains a leading cause of death globally, and its complexity poses a significant challenge to effective treatment. Cancer stem cells and their markers have become key players in tumor growth and progression. CD133, a marker in various cancer types, is an active research area as a potential therapeutic target. This article explores the role of CD133 in cancer treatment, beginning with an overview of cancer statistics and an explanation of cancer stem cells and their markers. The rise of CD133 is discussed, including its structure, functions, and occurrence in different cancer types. Furthermore, the article covers CD133 as a therapeutic target, focusing on gene therapy, immunotherapy, and approaches to affect CD133 expression. Nanoparticles such as gold nanoparticles and nanoliposomes are also discussed in the context of CD133-targeted therapy. In conclusion, CD133 is a promising therapeutic target for cancer treatment. As research in this area progresses, it is hoped that CD133-targeted therapies will offer new and effective treatment options for cancer patients in the future.
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页数：29
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