Using Typhoid Conjugate Vaccines to Prevent Disease, Promote Health Equity, and Counter Drug-Resistant Typhoid Fever

被引:12
作者
Nampota-Nkomba, Nginache [1 ]
Carey, Megan E. [2 ]
Jamka, Leslie P. [3 ,4 ]
Fecteau, Natalie [3 ]
Neuzil, Kathleen M. [3 ,4 ]
机构
[1] Kamuzu Univ Hlth Sci, Blantyre Malaria Project, Blantyre, Malawi
[2] Univ Cambridge, Cambridge Inst Therapeut Immunol & Infect Dis, Dept Med, Cambridge, England
[3] Univ Maryland, Ctr Vaccine Dev & Global Hlth, Sch Med, Baltimore, MD USA
[4] 685 W Baltimore St, 480, Baltimore, MD 21201 USA
关键词
drug-resistant Salmonella Typhi; health equity; typhoid conjugate vaccines; typhoid fever; SALMONELLA-TYPHI; OUTBREAK; SAFETY; IMMUNOGENICITY; CHILDREN; EFFICACY;
D O I
10.1093/ofid/ofad022
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Typhoid conjugate vaccines (TCVs) are safe, effective, and WHO-prequalified for children as young as 6 months. TCVs have the potential to prevent typhoid fever and advance health equity, while simultaneously slowing the emergence and spread of drug-resistant Salmonella Typhi strains. Typhoid fever is a serious disease that disproportionately impacts children in low-resource settings in sub-Saharan Africa, South and Southeast Asia, and the Western Pacific. The prevalence of antimicrobial-resistant strains of S. Typhi continue to increase worldwide. Two safe, effective, and cost-effective typhoid conjugate vaccines (TCVs) are World Health Organization-prequalified for the prevention of typhoid fever in children as young as 6 months. Typhoid conjugate vaccines have proven effectiveness in preventing drug-resistant S. Typhi and have been deployed successfully in outbreak response and routine immunization scenarios. Broad and equitable distribution of TCVs is essential to combat the spread and potentially devastating consequences of typhoid fever. It is vital to empower decision-makers in typhoid-endemic countries to introduce TCVs and for leaders to embrace this critical tool to prevent typhoid fever, slow the spread of drug-resistant S. Typhi strains, promote health equity, and save lives.
引用
收藏
页码:S6 / S12
页数:7
相关论文
共 57 条
[31]   The show is not over - wild-type polio in Malawi is a wake-up call and an opportunity for elimination efforts [J].
McCarthy, Kerrigan ;
Howard, Wayne ;
Yousif, Mukhlid ;
Moonsamy, Shelina ;
Suchard, Melinda .
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2022, 119 :32-33
[32]  
Mukhopadhyay J., PERSISTENT COVID 19
[33]   Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis [J].
Murray, Christopher J. L. ;
Ikuta, Kevin Shunji ;
Sharara, Fablina ;
Swetschinski, Lucien ;
Aguilar, Gisela Robles ;
Gray, Authia ;
Han, Chieh ;
Bisignano, Catherine ;
Rao, Puja ;
Wool, Eve ;
Johnson, Sarah C. ;
Browne, Annie J. ;
Chipeta, Michael Give ;
Fell, Frederick ;
Hackett, Sean ;
Haines-Woodhouse, Georgina ;
Hamadani, Bahar H. Kashef ;
Kumaran, Emmanuelle A. P. ;
McManigal, Barney ;
Agarwal, Ramesh ;
Akech, Samuel ;
Albertson, Samuel ;
Amuasi, John ;
Andrews, Jason ;
Aravkin, Aleskandr ;
Ashley, Elizabeth ;
Bailey, Freddie ;
Baker, Stephen ;
Basnyat, Buddha ;
Bekker, Adrie ;
Bender, Rose ;
Bethou, Adhisivam ;
Bielicki, Julia ;
Boonkasidecha, Suppawat ;
Bukosia, James ;
Carvalheiro, Cristina ;
Castaneda-Orjuela, Carlos ;
Chansamouth, Vilada ;
Chaurasia, Suman ;
Chiurchiu, Sara ;
Chowdhury, Fazle ;
Cook, Aislinn J. ;
Cooper, Ben ;
Cressey, Tim R. ;
Criollo-Mora, Elia ;
Cunningham, Matthew ;
Darboe, Saffiatou ;
Day, Nicholas P. J. ;
De Luca, Maia ;
Dokova, Klara .
LANCET, 2022, 399 (10325) :629-655
[34]  
Nampota-Nkomba N, 2022, LANCET GLOB HEALTH, V10, pE1326, DOI 10.1016/S2214-109X(22)00275-3
[35]  
Neuzil KM., LETS TALK TYPHOID PR, V2022
[36]  
Oberman E., TYPHOID CONJUGATE VA
[37]   Typhoid Vi-conjugate vaccine for outbreak control in Zimbabwe [J].
Olaru, Ioana D. ;
Mtapuri-Zinyowera, Sekesai ;
Feasey, Nicholas ;
Ferrand, Rashida A. ;
Kranzer, Katharina .
LANCET INFECTIOUS DISEASES, 2019, 19 (09) :930-930
[38]   Intestinal Perforations Associated With a High Mortality and Frequent Complications During an Epidemic of Multidrug-resistant Typhoid Fever in Blantyre, Malawi [J].
Olgemoeller, Franziska ;
Waluza, Jonathan J. ;
Zeka, Dalitso ;
Gauld, Jillian S. ;
Diggle, Peter J. ;
Read, Jonathan M. ;
Edwards, Thomas ;
Msefula, Chisomo L. ;
Chirambo, Angeziwa ;
Gordon, Melita A. ;
Thomson, Emma ;
Heyderman, Robert S. ;
Borgstein, Eric ;
Feasey, Nicholas A. .
CLINICAL INFECTIOUS DISEASES, 2020, 71 :S96-S101
[39]   Safety and Efficacy of a Typhoid Conjugate Vaccine in Malawian Children [J].
Patel, Priyanka D. ;
Patel, Pratiksha ;
Liang, Yuanyuan ;
Meiring, James E. ;
Misiri, Theresa ;
Mwakiseghile, Felistas ;
Tracy, J. Kathleen ;
Masesa, Clemens ;
Msuku, Harrison ;
Banda, David ;
Mbewe, Maurice ;
Henrion, Marc ;
Adetunji, Fiyinfolu ;
Simiyu, Kenneth ;
Rotrosen, Elizabeth ;
Birkhold, Megan ;
Nampota, Nginache ;
Nyirenda, Osward M. ;
Kotloff, Karen ;
Gmeiner, Markus ;
Dube, Queen ;
Kawalazira, Gift ;
Laurens, Matthew B. ;
Heyderman, Robert S. ;
Gordon, Melita A. ;
Neuzil, Kathleen M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (12) :1104-1115
[40]   The emergence of azithromycin-resistant Salmonella Typhi in Nepal [J].
Pham Thanh Duy ;
Dongol, Sabina ;
Giri, Abhishek ;
Nguyen Thi Nguyen To ;
Ho Ngoc Dan Thanh ;
Nguyen Pham Nhu Quynh ;
Pham Duc Trung ;
Thwaites, Guy E. ;
Basnyat, Buddha ;
Baker, Stephen ;
Rabaa, Maia A. ;
Karkey, Abhilasha .
JAC-ANTIMICROBIAL RESISTANCE, 2020, 2 (04)