The role of microbiota in the management of genitourinary syndrome of menopause

被引:4
作者
Stabile, G. [1 ]
Topouzova, G. A. [2 ]
De Seta, F. [1 ,2 ,3 ]
机构
[1] IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy
[2] Univ Trieste, Dept Med Surg & Hlth Sci, UCO Clin Ostetr & Ginecolog, Trieste, Italy
[3] IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Via Istria 65-1, Trieste, Italy
关键词
Genitourinary syndrome of menopause; menopause; microbiota; Lactobacilli; vulvovaginal atrophy; management; therapy; MICROABLATIVE FRACTIONAL CO2-LASER; POSTMENOPAUSAL WOMEN; VAGINAL MICROBIOTA; LACTOBACILLI; ATROPHY; SYMPTOMS; OSPEMIFENE; ESTRIOL; IMPROVE; FLORA;
D O I
10.1080/13697137.2023.2223923
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
It is estimated that the 25-50% of women who are reaching menopause every year report symptoms related to the genitourinary syndrome of menopause (GSM). The symptoms are not due simply to lack of estrogen. One possible contributing cause of symptoms is the vaginal microbiota. The vaginal microbiota is a dynamic entity and plays a critical role in the pathogenic interplay of postmenopausal changes. Treatment of this syndrome depends on the severity and type of the symptoms and on the preferences and expectations of women. As there are many treatment options, therapy should be individualized. While new evidence on the role of Lactobacilli in premenopause is emerging, the role of Lactobacilli is still unclear in GSM and the impact of microbiota on vaginal health remains conflictual. However, some reports show promising data on the effect of probiotic therapy in menopause. In the literature there are few studies and small population samples on the role of an exclusive therapy with Lactobacilli and further data will be mandatory. Studies involving large numbers of patients and different intervention periods will be necessary to obtain evidence of the preventive and curative role of vaginal probiotics.
引用
收藏
页码:353 / 360
页数:8
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