The Pyridotriazole Works as a Traceless Directing Group: A C-H Activation/Annulation Cascade Reaction with Iodonium Ylides

被引：13

作者：

Lv, Guanghui ^{[1
,2
]}

Zhang, Qingyao ^{[1
]}

Zhang, Cuimei ^{[1
]}

Chen, Yuting ^{[1
]}

Lin, Zheng ^{[1
]}

Lai, Ruizhi ^{[1
]}

Yang, Zhongzhen ^{[1
]}

Wu, Yong ^{[1
]}

机构：

[1] Sichuan Univ, West China Sch Pharm, Dept Med Chem, Key Lab Drug Targeting, Chengdu 610041, Sichuan, Peoples R China

[2] Hubei Univ Med, Taihe Hosp, Dept Pharm, Shiyan 442000, Hubei, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 22期

关键词：

CATALYZED DENITROGENATIVE TRANSANNULATION; ACTIVATION; ACCESS; ALKYNES; ANHYDROEXFOLIAMYCIN; REARRANGEMENT; METABOLITE; CARBENES; NITRONES; ARYL;

D O I：

10.1021/acs.orglett.3c01102

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel Rh-catalyzed cascade reaction of pyridotriazoleswith iodoniumylides is reported. This one-pot procedure involves a triazole-directed ortho-position C-H carbene insertion, followed byintramolecular denitrogenation annulation. It was noteworthy thatthis reaction provided straightforward access to 1H-isochromene frameworks with excellent yields (up to 94% yield).

引用

页码：4022 / 4027

页数：6

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