Increased levels of a subset of angiogenesis-related plasma proteins in essential thrombocythemia

被引：1

作者：

Vikman, Sofia ^{[1
,2
]}

Larsson, Anders ^{[1
,3
]}

Thulin, Mans ^{[4
]}

Karlsson, Torbjorn ^{[1
,2
]}

机构：

[1] Uppsala Univ, Dept Med Sci, Uppsala, Sweden

[2] Univ Uppsala Hosp, Dept Haematol, Uppsala, Sweden

[3] Univ Uppsala Hosp, Dept Clin Chem, Uppsala, Sweden

[4] Uppsala Univ, Dept Math, Uppsala, Sweden

来源：

UPSALA JOURNAL OF MEDICAL SCIENCES | 2023年 / 128卷 / 01期

关键词：

Essential thrombocythemia; angiogenesis; extracellular matrix; matrix metallopeptidase 9; endostatin; E-SELECTIN; CELLS; LYMPHANGIOGENESIS; DISCOVERY; DISEASE; GENE; VEGF;

D O I：

10.48101/ujms.v128.9194

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Increased local angiogenesis is important for the growth and dissemination of cancer. The myeloproliferative neoplasm essential thrombocythemia (ET) is known to involve increased bone marrow angiogenesis. Blood levels of several angiogenesis-related proteins are increased in different types of cancer. The aim of this study was to investigate whether a subset of such proteins was elevated in treatment-naive ET patients. Methods: Blood plasma from 41 ET patients and 43 healthy aged-matched controls was analyzed for eight different angiogenesis-related proteins. Results: The ET cohort displayed a more homogenous expression pattern of these proteins compared with controls. Five of the eight proteins were significantly increased in ET patients. Conclusion: Increased plasma levels of matrix metallopeptidase 9 (MMP9) and endostatin have not previously been reported in ET. In our patients, MMP9 levels correlated positively with Janus kinase 2 (JAK2) V617F allele burden and leukocyte count.

引用

页数：6

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