Synthesis and Analgesic and Anti-Inflammatory Activity of 5-Aryl-4-(4-Halobenzoyl)-3-Hydroxy-1-Carboxymethyl-3-PyrroliN-2-Ones

被引：0

作者：

Pastukhova, E. V. ^{[1
]}

Chashchina, S. V. ^{[1
,2
]}

Buldakova, E. A. ^{[1
]}

Gein, V. L. ^{[1
]}

Mokrushin, I. G. ^{[2
]}

机构：

[1] Perm State Pharmaceut Acad, 2 Polevaya St, Perm 614990, Russia

[2] Perm State Natl Res Univ, 15 Bukireva St, Perm 614990, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2023年 / 57卷 / 02期

关键词：

5-aryl-4-(4-halobenzoyl)-3-hydroxy-1-carboxymethyl-3-pyrrolin-2-ones; three-component reactions; analgesic activity; anti-inflammatory activity;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

5-Aryl-4-(4-halobenzoyl)-3-hydroxy-1-carboxymethyl-3-pyrrolin-2-ones were obtained by a three-component reaction of methyl esters of p-halobenzoylpyruvic acids with a mixture of aromatic aldehyde and glycine in glacial acetic acid in the presence of anhydrous sodium acetate. The analgesic activity of the obtained compounds was studied using the hot-plate method. Their anti-inflammatory activity was determined using the aseptic carrageenan inflammation model. It was shown that all compounds under study exhibit pronounced analgesic activity while compound III also had pronounced anti-exudative activity.

引用

页码：204 / 208

页数：5

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