TGF-β Regulation of T Cells

被引：78

作者：

Chen, WanJun ^{[1
]}

机构：

[1] Natl Inst Dent & Craniofacial Res, Mucosal Immunol Sect, NIH, Bethesda, MD 20892 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2023年 / 41卷

关键词：

CD4(+) T helper cells; CD8(+) T cells; regulatory T cells; innate lymphoid cells; intraepithelial lymphocytes; gamma delta T cells; T cell quiescence and activation; GROWTH-FACTOR-BETA; INNATE LYMPHOID-CELLS; TRANSCRIPTION FACTOR; IL-9; PRODUCTION; T(H)17 CELLS; IMMUNE-RESPONSES; FOXP3; EXPRESSION; GENE-EXPRESSION; DENDRITIC CELLS; NKT CELLS;

D O I：

10.1146/annurev-immunol-101921-045939

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transforming growth factor beta (TGF-beta) is a key cytokine regulating the development, activation, proliferation, differentiation, and death of T cells. In CD4(+) T cells, TGF-beta maintains the quiescence and controls the activation of naive T cells. While inhibiting the differentiation and function of Th1 and Th2 cells, TGF-beta promotes the differentiation of Th17 and Th9 cells. TGF-beta is required for the induction of Foxp3 in naive T cells and the development of regulatory T cells. TGF-beta is crucial in the differentiation of tissue-resident memory CD8(+) T cells and their retention in the tissue, whereas it suppresses effector T cell function. In addition, TGF-beta also regulates the generation or function of natural killer T cells, gamma delta T cells, innate lymphoid cells, and gut intraepithelial lymphocytes. Here I highlight the major findings and recent advances in our understanding of TGF-beta regulation of T cells and provide a personal perspective of the field.

引用

页码：483 / 512

页数：30

共 209 条

[51] Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells [J].

Ferreira, Cristina ;

Barros, Leandro ;

Baptista, Marta ;

Blankenhaus, Birte ;

Barros, Andre ;

Figueiredo-Campos, Patricia ;

Konjar, Spela ;

Laine, Alexandra ;

Kamenjarin, Nadine ;

Stojanovic, Ana ;

Cerwenka, Adelheid ;

Probst, Hans C. ;

Marie, Julien C. ;

Veldhoen, Marc .

NATURE IMMUNOLOGY, 2020, 21 (07) :766-+

[52] The polarization of immune cells in the tumour environment by TGFβ [J].

Flavell, Richard A. ;

Sanjabi, Shomyseh ;

Wrzesinski, Stephen H. ;

Licona-Limon, Paula .

NATURE REVIEWS IMMUNOLOGY, 2010, 10 (08) :554-567

[53] Epigenetic control of the foxp3 locus in regulatory T cells [J].

Floess, Stefan ;

Freyer, Jennifer ;

Siewert, Christiane ;

Baron, Udo ;

Olek, Sven ;

Polansky, Julia ;

Schlawe, Kerstin ;

Chang, Hyun-Dong ;

Bopp, Tobias ;

Schmitt, Edgar ;

Klein-Hessling, Stefan ;

Serfling, Edgar ;

Hamann, Alf ;

Huehn, Jochen .

PLOS BIOLOGY, 2007, 5 (02) :169-178

[54] Foxp3 Programs the Development and Function of CD4+CD25+ Regulatory T Cells (Reprinted from vol 4, pg 330-336, 2003) [J].

Fontenot, Jason D. ;

Gavin, Marc A. ;

Rudensky, Alexander Y. .

JOURNAL OF IMMUNOLOGY, 2017, 198 (03) :986-992

[55] TGF-β induces Foxp3+T-regulatory cells from CD4+CD25-precursors [J].

Fu, S ;

Zhang, N ;

Yopp, AC ;

Chen, DM ;

Mao, MW ;

Chen, D ;

Zhang, HJ ;

Ding, YZ ;

Bromberg, JS .

AMERICAN JOURNAL OF TRANSPLANTATION, 2004, 4 (10) :1614-1627

[56] Transforming growth factor-b-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection [J].

Gabriel, Sarah S. ;

Tsui, Carlson ;

Chisanga, David ;

Weber, Flora ;

Llano-Leon, Manuela ;

Gubser, Patrick M. ;

Bartholin, Laurent ;

Souza-Fonseca-Guimaraes, Fernando ;

Huntington, Nicholas D. ;

Shi, Wei ;

Utzschneider, Daniel T. ;

Kallies, Axel .

IMMUNITY, 2021, 54 (08) :1698-+

[57] Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells [J].

Gao, Yulong ;

Souza-Fonseca-Guimaraes, Fernando ;

Bald, Tobias ;

Ng, Susanna S. ;

Young, Arabella ;

Ngiow, Shin Foong ;

Rautela, Jai ;

Straube, Jasmin ;

Waddell, Nic ;

Blake, Stephen J. ;

Yan, Juming ;

Bartholin, Laurent ;

Lee, Jason S. ;

Vivier, Eric ;

Takeda, Kazuyoshi ;

Messaoudene, Meriem ;

Zitvogel-, Laurence ;

Teng, Michele W. L. ;

Belz, Gabrielle T. ;

Engwerda, Christian R. ;

Huntington, Nicholas D. ;

Nakamura, Kyohei ;

Hoelzel, Michael ;

Smyth, Mark J. .

NATURE IMMUNOLOGY, 2017, 18 (09) :1004-+

[58] T-cell TGF-β signaling abrogation restricts medulloblastoma progression [J].

Gate, David ;

Danielpour, Moise ;

Rodriguez, Javier, Jr. ;

Kim, Gi-Bum ;

Levy, Rachelle ;

Bannykh, Serguei ;

Breunig, Joshua J. ;

Kaech, Susan M. ;

Flavell, Richard A. ;

Town, Terrence .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (33) :E3458-E3466

[59] T helper 17 cell heterogeneity and pathogenicity in autoimmune disease [J].

Ghoreschi, Kamran ;

Laurence, Arian ;

Yang, Xiang-Ping ;

Hirahara, Kiyoshi ;

O'Shea, John J. .

TRENDS IN IMMUNOLOGY, 2011, 32 (09) :395-401

[60] Generation of pathogenic TH17 cells in the absence of TGF-β signalling [J].

Ghoreschi, Kamran ;

Laurence, Arian ;

Yang, Xiang-Ping ;

Tato, Cristina M. ;

McGeachy, Mandy J. ;

Konkel, Joanne E. ;

Ramos, Haydee L. ;

Wei, Lai ;

Davidson, Todd S. ;

Bouladoux, Nicolas ;

Grainger, John R. ;

Chen, Qian ;

Kanno, Yuka ;

Watford, Wendy T. ;

Sun, Hong-Wei ;

Eberl, GerRard ;

Shevach, EthanM. ;

Belkaid, Yasmine ;

Cua, Daniel J. ;

Chen, WanJun ;

O'Shea, John J. .

NATURE, 2010, 467 (7318) :967-U144

← 1 2 3 4 5 6 7 8 9 10 →