Radiopharmaceuticals heat anti-tumor immunity

被引：15

作者：

Sun, Qi ^{[1
]}

Li, Jiyuan ^{[2
]}

Ding, Zexuan ^{[3
]}

Liu, Zhibo ^{[1
,2
,3
]}

机构：

[1] Peking Univ, Tsinghua Univ, Acad Adv Interdisciplinary Studies, Ctr Life Sci, Beijing 100871, Peoples R China

[2] Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci Radiochem & Radiat Chem, Key Lab Fundamental Sci, Beijing 100871, Peoples R China

[3] Changping Lab, Beijing 102206, Peoples R China

来源：

THERANOSTICS | 2023年 / 13卷 / 02期

关键词：

anti-tumor immunity; radiopharmaceutical therapy (RPT); immunogenic cell death (ICD); LOCAL RADIATION-THERAPY; RA; 223; DICHLORIDE; TUMOR-CELL DEATH; CHECKPOINT BLOCKADE; RADIONUCLIDE THERAPY; CALRETICULIN EXPOSURE; MOUSE MODEL; T-CELLS; CANCER; RADIOTHERAPY;

D O I：

10.7150/thno.79806

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Radiopharmaceutical therapy (RPT) has proven to be an effective cancer treatment with minimal toxicity. With several RPT agents approved by FDA, the remarkable potential of this therapy is now being recognized, and the anti-tumor immunity induced by RPT is beginning to be noticed. This review evaluates the potential of RPT for immune activation, including promoting the release of danger associated-molecular pattern molecules that recruit inflammatory cells into the tumor microenvironment, and activating antigen-presenting cells and cytotoxic T cells. We also discuss the progress of combining RPT with immunotherapy to increase efficacy.

引用

页码：767 / 786

页数：20

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