Effects of Particle Size of Curcumin Solid Dispersions on Bioavailability and Anti-Inflammatory Activities

被引:6
|
作者
Kato, Chihiro [1 ]
Itaya-Takahashi, Mayuko [1 ]
Miyazawa, Taiki [2 ]
Ito, Junya [1 ]
Parida, Isabella Supardi [1 ]
Yamada, Hiroki [1 ]
Abe, Akari [3 ]
Shibata, Mika [3 ]
Someya, Keita [3 ]
Nakagawa, Kiyotaka [1 ]
机构
[1] Tohoku Univ, Grad Sch Agr Sci, Lab Food Funct Anal, 468-1 Aramaki Aza Aoba,Aoba ku, Sendai 9808572, Japan
[2] Tohoku Univ, New Ind Creat Hatchery Ctr NICHe, 6-6-10 Aramaki Aza Aoba,Aoba ku, Sendai 9808579, Japan
[3] Yokohama Oils & Fats Ind Co Ltd, 380-7 Horiyamashita, Hadano 2591304, Japan
关键词
anti-inflammatory; bioavailability; cellular uptake; curcumin; curcumin glucuronide; intravenous administration; metabolism; nanoparticles; oral administration; particle size; ORAL BIOAVAILABILITY; MICROPARTICLES; NANOPARTICLES; GLUCURONIDE; DELIVERY;
D O I
10.3390/antiox12030724
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The delivery of curcumin (CUR) using the solid dispersion system (CUR solid dispersions; C-SDs) has been shown to improve CUR bioavailability. However, it is unclear how different particle sizes of C-SDs affect the bioavailability and biological activities of CUR. Hence, we prepared C-SDs in different sizes using food-grade excipients and evaluated their bioavailability and biological activities. By pulverizing large particle sizes of C-SDs using zirconia beads, we successfully prepared C-SDs I-IV (particle size: (I) 120, (II) 447, (III) 987, (IV) 1910 nm). When administrated orally in rats, the bioavailability of CUR was increased with decreasing C-SDs size, most likely by improving its solubility in micelles. When administrated intravenously in rats, blood concentrations of CUR were increased with increasing particle size, suggesting that larger C-SDs presumably control the metabolic conversion of CUR. In RAW264 cells, more CUR was taken up by cells as their sizes reduced, and the more potent their anti-inflammatory activities were, suggesting that smaller C-SDs were taken up through a number of cellular uptake pathways. Altogether, the present study showed an evident effect of C-SDs size on their bioavailability and anti-inflammatory activities-information that serves as a basis for improving the functionality of CUR.
引用
收藏
页数:14
相关论文
共 50 条
  • [1] Anti-inflammatory effects of a solid lipid curcumin particle formulation
    Nahar, Pragati
    Driscoll, Maureen
    Slitt, Angela
    Seeram, Navindra P.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
  • [2] Influence of particle size on the in vitro and in vivo anti-inflammatory and anti-allergic activities of a curcumin lipid nanoemulsion
    Onodera, Takefumi
    Kuriyama, Isoko
    Andoh, Tooru
    Ichikawa, Hideki
    Sakamoto, Yuka
    Lee-Hiraiwa, Eibai
    Mizushina, Yoshiyuki
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2015, 35 (06) : 1720 - 1728
  • [3] Microparticles Containing Curcumin Solid Dispersion: Stability, Bioavailability and Anti-Inflammatory Activity
    Teixeira, C. C. C.
    Mendonca, L. M.
    Bergamaschi, M. M.
    Queiroz, R. H. C.
    Souza, G. E. P.
    Antunes, L. M. G.
    Freitas, L. A. P.
    AAPS PHARMSCITECH, 2016, 17 (02): : 252 - 261
  • [4] Microparticles Containing Curcumin Solid Dispersion: Stability, Bioavailability and Anti-Inflammatory Activity
    C. C. C. Teixeira
    L. M. Mendonça
    M. M. Bergamaschi
    R. H. C. Queiroz
    G. E. P. Souza
    L. M. G. Antunes
    L. A. P. Freitas
    AAPS PharmSciTech, 2016, 17 : 252 - 261
  • [5] The pharmacokinetics and anti-inflammatory effects of chelerythrine solid dispersions in vivo
    Li, Weifeng
    Qing, Sun
    Zhi, Wenbing
    Yao, Huan
    Fu, Chenglong
    Niu, Xiaofeng
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2017, 40 : 51 - 58
  • [6] Curcumin-loaded soluplus® based ternary solid dispersions with enhanced solubility, dissolution and antibacterial, antioxidant, anti-inflammatory activities
    Ishtiaq, Memoona
    Manzoor, Hina
    Khan, Ikram Ullah
    Asghar, Sajid
    Irfan, Muhammad
    Albekairi, Norah A.
    Alshammari, Abdulrahman
    Alqahtani, Abdulrahman F.
    Alotaibi, Saad
    Munir, Rabia
    Shah, Pervaiz A.
    Hussain, Liaqat
    Saleem, Muhammad Abubakar
    Razzaq, Fizza Abdul
    Khalid, Syed Haroon
    HELIYON, 2024, 10 (14)
  • [7] Anti-Inflammatory Effects of Novel Standardized Solid Lipid Curcumin Formulations
    Nahar, Pragati P.
    Slitt, Angela L.
    Seeram, Navindra P.
    JOURNAL OF MEDICINAL FOOD, 2015, 18 (07) : 786 - 792
  • [8] ANTI-INFLAMMATORY AND IRRITANT ACTIVITIES OF CURCUMIN ANALOGS IN RATS
    MUKHOPADHYAY, A
    BASU, N
    GHATAK, N
    GUJRAL, PK
    AGENTS AND ACTIONS, 1982, 12 (04): : 508 - 515
  • [9] Curcumin amorphous solid dispersions benefit from hydroxypropyl methylcellulose E50 to perform enhanced anti-inflammatory effects
    Zhang, Jiayi
    Shi, Xianbao
    Tao, Wei
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 252
  • [10] Improvement of Bioavailability and Anti-Inflammatory Potential of Curcumin in Combination with Emu Oil
    Manish Kumar Jeengar
    Shweta Shrivastava
    Kala Nair
    Sreenivasa Reddy Singareddy
    Uday Kumar Putcha
    M. V. N. Kumar Talluri
    V. G. M. Naidu
    Ramakrishna Sistla
    Inflammation, 2014, 37 : 2139 - 2155