Innate immune biology in age-related macular degeneration

被引：9

作者：

Ascunce, Karina ^{[1
]}

Dhodapkar, Rahul M. M. ^{[2
]}

Huang, Deven ^{[3
]}

Hafler, Brian P. P. ^{[4
,5
]}

机构：

[1] Yale Univ, Interdept Neurosci Program, New Haven, CT USA

[2] Univ Southern Calif, Roski Eye Inst, Dept Ophthalmol, Los Angeles, CA USA

[3] Choate Rosemary Hall, Wallingford, CT USA

[4] Yale Univ, Dept Ophthalmol & Visual Sci, New Haven, CT 06520 USA

[5] Yale Univ, Dept Pathol, New Haven, CT 06520 USA

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷

关键词：

neuroinflammation; age-related macular degeneration (AMD); neurodegeneration; neuroimmune biology; innate immunity; DENDRITIC CELLS; CHOROIDAL NEOVASCULARIZATION; PERIVASCULAR MACROPHAGES; T-CELLS; MONOCYTES; DISEASE; LESIONS; HEALTH; RISK;

D O I：

10.3389/fcell.2023.1118524

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Age-related macular degeneration (AMD) is a neurodegenerative disease and a leading cause of irreversible vision loss in the developed world. While not classically described as an inflammatory disease, a growing body of evidence has implicated several components of the innate immune system in the pathophysiology of age-related macular degeneration. In particular, complement activation, microglial involvement, and blood-retinal-barrier disruption have been shown to play key roles in disease progression, and subsequent vision loss. This review discusses the role of the innate immune system in age-related macular degeneration as well as recent developments in single-cell transcriptomics that help advance the understanding and treatment of age-related macular degeneration. We also explore the several potential therapeutic targets for age-related macular degeneration in the context of innate immune activation.

引用

页数：6

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