Innate immune biology in age-related macular degeneration

被引：9
作者：
Ascunce, Karina [1 ]
Dhodapkar, Rahul M. M. [2 ]
Huang, Deven [3 ]
Hafler, Brian P. P. [4 ,5 ]
机构：
[1] Yale Univ, Interdept Neurosci Program, New Haven, CT USA
[2] Univ Southern Calif, Roski Eye Inst, Dept Ophthalmol, Los Angeles, CA USA
[3] Choate Rosemary Hall, Wallingford, CT USA
[4] Yale Univ, Dept Ophthalmol & Visual Sci, New Haven, CT 06520 USA
[5] Yale Univ, Dept Pathol, New Haven, CT 06520 USA
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷
关键词：
neuroinflammation; age-related macular degeneration (AMD); neurodegeneration; neuroimmune biology; innate immunity; DENDRITIC CELLS; CHOROIDAL NEOVASCULARIZATION; PERIVASCULAR MACROPHAGES; T-CELLS; MONOCYTES; DISEASE; LESIONS; HEALTH; RISK;
D O I：
10.3389/fcell.2023.1118524
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Age-related macular degeneration (AMD) is a neurodegenerative disease and a leading cause of irreversible vision loss in the developed world. While not classically described as an inflammatory disease, a growing body of evidence has implicated several components of the innate immune system in the pathophysiology of age-related macular degeneration. In particular, complement activation, microglial involvement, and blood-retinal-barrier disruption have been shown to play key roles in disease progression, and subsequent vision loss. This review discusses the role of the innate immune system in age-related macular degeneration as well as recent developments in single-cell transcriptomics that help advance the understanding and treatment of age-related macular degeneration. We also explore the several potential therapeutic targets for age-related macular degeneration in the context of innate immune activation.
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页数：6
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