Compact Modeling of Two-Dimensional Field-Effect Biosensors

被引:7
|
作者
Pasadas, Francisco [1 ]
El Grour, Tarek [2 ]
Marin, Enrique G. [1 ]
Medina-Rull, Alberto [1 ]
Toral-Lopez, Alejandro [1 ]
Cuesta-Lopez, Juan [1 ]
Ruiz, Francisco G. [1 ]
El Mir, Lassaad [2 ]
Godoy, Andres [1 ]
机构
[1] Univ Granada, Dept Elect & Tecnol Comp, Pervas Elect Adv Res Lab PEARL, Granada 18071, Spain
[2] Gabes Univ, Fac Sci Gabes, Lab Phys Mat & Nanomat Appl Environm LaPhyMNE LR05, Gabes 6072, Tunisia
关键词
2D; biosensor; field-effect transistor; immunosensor; modeling; MoS2; sensor; TMD; two-dimensional; Verilog-A; CURRENT-VOLTAGE MODEL; LABEL-FREE DETECTION; EFFECT-TRANSISTOR; DOUBLE-LAYER; ELECTRONIC-STRUCTURE; GRAPHENE; DNA; MACROMODEL; ACCURATE; LIGANDS;
D O I
10.3390/s23041840
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A compact model able to predict the electrical read-out of field-effect biosensors based on two-dimensional (2D) semiconductors is introduced. It comprises the analytical description of the electrostatics including the charge density in the 2D semiconductor, the site-binding modeling of the barrier oxide surface charge, and the Stern layer plus an ion-permeable membrane, all coupled with the carrier transport inside the biosensor and solved by making use of the Donnan potential inside the ion-permeable membrane formed by charged macromolecules. This electrostatics and transport description account for the main surface-related physical and chemical processes that impact the biosensor electrical performance, including the transport along the low-dimensional channel in the diffusive regime, electrolyte screening, and the impact of biological charges. The model is implemented in Verilog-A and can be employed on standard circuit design tools. The theoretical predictions obtained with the model are validated against measurements of a MoS2 field-effect biosensor for streptavidin detection showing excellent agreement in all operation regimes and leading the way for the circuit-level simulation of biosensors based on 2D semiconductors.
引用
收藏
页数:16
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