Chitosan-based nano drug delivery system for lung cancer

被引：10

作者：

Kazmi, Imran ^{[1
]}

Shaikh, Mohammad Arshad Javed ^{[2
,3
]}

Afzal, Obaid ^{[4
]}

Altamimi, Abdulmalik Saleh Alfawaz ^{[4
]}

Almalki, Waleed Hassan ^{[5
]}

Alzarea, Sami I. ^{[6
]}

Al-Abbasi, Fahad A. ^{[1
]}

Pandey, Manisha ^{[7
]}

Dureja, Harish ^{[8
]}

Singh, Sachin Kumar ^{[9
,10
]}

Dua, Kamal ^{[10
,11
]}

Gupta, Gaurav ^{[2
,12
,13
]}

机构：

[1] King Abdulaziz Univ, Fac Sci, Dept Biochem, Jeddah, Saudi Arabia

[2] Suresh Gyan Vihar Univ, Sch Pharm, Mahal Rd, Jaipur 302017, India

[3] TPCTs Coll Engn, Dept Pharm, Osmanabad, Maharashtra, India

[4] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut Chem, Al Kharj 11942, Saudi Arabia

[5] Umm Al Qura Univ, Coll Pharm, Dept Pharmacol, Mecca, Saudi Arabia

[6] Jouf Univ, Coll Pharm, Dept Pharmacol, Sakaka, Al Jouf, Saudi Arabia

[7] Cent Univ Haryana, Dept Pharmaceut Sci, Mahendergarh 123031, India

[8] Maharshi Dayanand Univ, Dept Pharmaceut Sci, Rohtak 124001, India

[9] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India

[10] Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Ultimo, NSW 2007, Australia

[11] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Sydney, NSW 2007, Australia

[12] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Dent Coll, Dept Pharmacol, Chennai, India

[13] Uttaranchal Univ, Uttaranchal Inst Pharmaceut Sci, Dehra Dun, India

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2023年 / 81卷

关键词：

Chitosan; Nano formulation; Non-small-cell-lung-cancer; Small-cell-lung-cancer; COATED PLGA NANOPARTICLES; HYALURONIC-ACID; ANTICANCER ACTIVITY; CYTOTOXICITY; HYDROGELS; SIRNA;

D O I：

10.1016/j.jddst.2023.104196

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lung cancer is a broad term that encompasses several subtypes of the leading cause of cancer-related mortality. Despite substantial gains in studying pulmonary tumor biology, advancements in earlier detection and multi-modal management, and unraveling genetic routes of drug resistance, total curative results are still limited, particularly in metastatic illness. Tumor diagnosis and treatment are being impacted by nanotechnology, particularly nanoparticles (NPs). To manage lung tumors, nanoscale components have unique physical and chemical characteristics that enable a broader range of molecular instruments. As chitosan nanoparticles can adjust release rates and precisely transport chemotherapeutic drugs, they alleviate the limitations of conven-tional anti-cancer treatments while simultaneously making them more effective and cost-efficient than ever before. As a drug carrier, chitosan's mucoadhesive, permeation-enhancing, and site/cell-specific properties play a significant role in its performance. Microencapsulation and micro-nano mixing systems have been designed for nanocarriers to enable efficient pulmonary aerosolization and inhalation and a wide range of nanocarriers. As part of this review, we emphasize the advances and opportunities connected with using chitosan-coated nano-medicines for lung cancer treatment and the hurdles involved with clinical translation in this sector.

引用

页数：11