Apathy in patients with Alzheimer's disease is a cost-driving factor

被引：5

作者：

Kruse, Christopher ^{[1
]}

Maier, Franziska ^{[2
]}

Spottke, Annika ^{[3
,4
]}

Bach, Jan-Philipp ^{[5
]}

Bartels, Claudia ^{[6
]}

Buerger, Katharina ^{[7
,8
]}

Fellgiebel, Andreas ^{[9
]}

Fliessbach, Klaus ^{[3
]}

Frolich, Lutz ^{[10
]}

Hausner, Lucrezia ^{[11
]}

Hellmich, Martin ^{[11
]}

Kloppel, Stefan ^{[12
]}

Klostermann, Arne ^{[13
,14
]}

Kornhuber, Johannes ^{[15
]}

Laske, Christoph ^{[16
,17
,18
]}

Peters, Oliver ^{[13
,14
]}

Priller, Josef ^{[13
,19
,20
]}

Richter-Schmidinger, Tanja ^{[15
]}

Schneider, Anja ^{[3
,21
]}

Shah-Hosseini, Kija ^{[11
]}

Teipel, Stefan ^{[22
,23
]}

von Arnim, Christine A. F. ^{[24
]}

Wiltfang, Jens ^{[6
,25
]}

van der Wurp, Hendrik ^{[1
,26
]}

Dodel, Richard ^{[1
,5
]}

Jessen, Frank ^{[2
,3
,27
]}

机构：

[1] Univ Duisburg Essen, Ctr Translat Neurol & Behav Res, Dept Geriatr Med, Duisburg, Germany

[2] Univ Hosp Cologne, Med Fac, Dept Psychiat, Kerpener Str 62, D-50924 Cologne, Germany

[3] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[4] Univ Bonn, Dept Neurol, Bonn, Germany

[5] Philipps Univ Marburg, Dept Neurol, Marburg, Germany

[6] Georg August Univ, Univ Med Ctr Goettingen UMG, Dept Psychiat & Psychotherapy, Gottingen, Germany

[7] Ludwig Maximilians Univ LMU, Klinikum Univ Munchen, Inst Stroke & Dementia Res, Munich, Germany

[8] German Ctr Neurodegenerat Dis DZNE, Munich, Germany

[9] Landeskrankenhaus AoR, Ctr Mental Hlth Old Age, Mainz, Germany

[10] Heidelberg Univ, Zent Inst Seel Gesundheit Mannheim, Dept Geriatr Psychiat, Mannheim, Germany

[11] Univ Cologne, Fac Med, Inst Med Stat & Computat Biol, Cologne, Germany

[12] Univ Bern, Univ Hosp Old Age Psychiat, Bern, Switzerland

[13] German Ctr Neurodegenerat Dis DZNE, Berlin, Germany

[14] Charite, Dept Psychiat, Berlin, Germany

[15] Friedrich Alexander Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, Erlangen, Germany

[16] German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany

[17] Univ Tubingen, Hertie Inst Clin Brain Res, Sect Dementia Res, Tubingen, Germany

[18] Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany

[19] Charite, Dept Neuropsychiat, Berlin, Germany

[20] Berlin Inst Hlth, Berlin, Germany

[21] Univ Bonn, Klin Neurodegenerat Erkrankungen & Gerontopsychia, Bonn, Germany

[22] German Ctr Neurodegenerat Dis DZNE, Rostock, Germany

[23] Univ Hosp Rostock, Dept Psychosomat Med, Rostock, Germany

[24] Ulm Univ Hosp, Dept Neurol, Ulm, Germany

[25] German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany

[26] TU Dortmund Univ, Dept Stat, Dortmund, Germany

[27] Univ Cologne, Excellence Cluster Cellular Stress Responses Agin, Cologne, Germany

来源：

ALZHEIMERS & DEMENTIA | 2023年 / 19卷 / 07期

关键词：

Alzheimer's disease; apathy; cost of illness; dementia; economics; resource use; NEUROPSYCHIATRIC SYMPTOMS; DEMENTIA; CARE; PREVALENCE; INVENTORY; GERMANY; TRIALS; MODELS; SCALE;

D O I：

10.1002/alz.12915

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BackgroundApathy is the most frequent neuropsychiatric symptom in patients with dementia of the Alzheimer's type (DAT). We analyzed the influence of apathy on the resource use of DAT patients and their caregivers. MethodsIncluded were baseline data of 107 DAT patients from a randomized clinical trial on apathy treatment. The Resource Utilization in Dementia (RUD) instrument assessed costs over a 1-month period prior to baseline. Cost predictors were determined via a least absolute shrinkage and selection operator (LASSO). ResultsOn average, total monthly costs were euro3070, of which euro2711 accounted for caregivers' and euro359 for patients' costs. An increase of one point in the Apathy Evaluation Scale resulted in a 4.1% increase in total costs. DiscussionApathy is a significant cost driving factor for total costs in mild to moderate DAT. Effective treatment of apathy might be associated with reduced overall costs in DAT.

引用

页码：2853 / 2864

页数：12

共 50 条

[41] Decision cost hypersensitivity underlies Huntington's disease apathy
Morris, Lee-Anne
Horne, Kyla-Louise
Manohar, Sanjay
Paermentier, Laura
Buchanan, Christina M.
Macaskill, Michael R.
Myall, Daniel J.
Apps, Matthew
Roxburgh, Richard
Anderson, Tim J.
Husain, Masud
Le Heron, Campbell J.
BRAIN, 2025, 148 (03) : 861 - 874
[42] Validation of apathy evaluation scale and assessment of severity of apathy in Alzheimer's disease
Hsieh, Chia-Jung
Chu, Hsin
Cheng, Joseph Jror-Serk
Shen, Winston W.
Lin, Chia-Chin
PSYCHIATRY AND CLINICAL NEUROSCIENCES, 2012, 66 (03) : 227 - 234
[43] Lack of Association Between COMT Polymorphisms and Apathy in Alzheimer's Disease
David, Renaud
Friedman, Leah
Mulin, Emmanuel
Noda, Art
Le Duff, Franck
Kennedy, Quinn
Garcia, Rene
Robert, Philippe H.
Yesavage, Jerome A.
Zeitzer, Jamie M.
JOURNAL OF ALZHEIMERS DISEASE, 2011, 27 (01) : 155 - 161
[44] Apathy-like behaviour in tau mouse models of Alzheimer's disease and frontotemporal dementia
Robinson, Lianne
Dreesen, Eline
Mondesir, Miguel
Harrington, Charles
Wischik, Claude
Riedel, Gernot
BEHAVIOURAL BRAIN RESEARCH, 2024, 456
[45] Apathy Syndrome in Alzheimer's Disease Epidemiology: Prevalence, Incidence, Persistence, and Risk and Mortality Factors
Vilalta-Franch, Joan
Calvo-Perxas, Laia
Garre-Olmo, Josep
Turro-Garriga, Oriol
Lopez-Pousa, Secundino
JOURNAL OF ALZHEIMERS DISEASE, 2013, 33 (02) : 535 - 543
[46] The link between apathy and Alzheimer's Disease: The role of psychometric tools and the possible implications for treatment
Furneri, Giovanna
Razza, Grazia
Santagati, Mario
Drago, Filippo
Di Nuovo, Santo
Caraci, Filippo
LIFE SPAN AND DISABILITY, 2021, 24 (01) : 85 - 111
[47] Psychometric properties of the apathy evaluation scale in patients with Parkinson's disease
Lueken, Ulrike
Evens, Ricarda
Balzer-Geldsetzer, Monika
Baudrexel, Simon
Dodel, Richard
Graeber-Sultan, Susanne
Hilker-Roggendorf, Ruediger
Kalbe, Elke
Kaut, Oliver
Mollenhauer, Brit
Reetz, Kathrin
Schaeffer, Eva
Schmidt, Nele
Schulz, Joerg B.
Spottke, Annika
Witt, Karsten
Linse, Katharina
Storch, Alexander
Riedel, Oliver
INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH, 2017, 26 (04)
[48] Neurobiology of apathy in Alzheimer's disease
Guimaraes, Henrique Cerqueira
Levy, Richard
Teixeira, Antonio Lucio
Beato, Rogerio Gomes
Caramelli, Paulo
ARQUIVOS DE NEURO-PSIQUIATRIA, 2008, 66 (2B) : 436 - 443
[49] Anosognosia Is a Significant Predictor of Apathy in Alzheimer's Disease
Starkstein, Sergio E.
Brockman, Simone
Bruce, David
Petracca, Gustavo
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, 2010, 22 (04) : 378 - 383
[50] Apathy in Alzheimer?s disease: A neurocircuitry based perspective
Mehak, Sonam Fathima
Shivakumar, Apoorva Bettagere
Saraf, Vikyath
Johansson, Maurits
Gangadharan, Gireesh
AGEING RESEARCH REVIEWS, 2023, 87

← 1 2 3 4 5 →