Apathy in patients with Alzheimer's disease is a cost-driving factor

被引：5

作者：

Kruse, Christopher ^{[1
]}

Maier, Franziska ^{[2
]}

Spottke, Annika ^{[3
,4
]}

Bach, Jan-Philipp ^{[5
]}

Bartels, Claudia ^{[6
]}

Buerger, Katharina ^{[7
,8
]}

Fellgiebel, Andreas ^{[9
]}

Fliessbach, Klaus ^{[3
]}

Frolich, Lutz ^{[10
]}

Hausner, Lucrezia ^{[11
]}

Hellmich, Martin ^{[11
]}

Kloppel, Stefan ^{[12
]}

Klostermann, Arne ^{[13
,14
]}

Kornhuber, Johannes ^{[15
]}

Laske, Christoph ^{[16
,17
,18
]}

Peters, Oliver ^{[13
,14
]}

Priller, Josef ^{[13
,19
,20
]}

Richter-Schmidinger, Tanja ^{[15
]}

Schneider, Anja ^{[3
,21
]}

Shah-Hosseini, Kija ^{[11
]}

Teipel, Stefan ^{[22
,23
]}

von Arnim, Christine A. F. ^{[24
]}

Wiltfang, Jens ^{[6
,25
]}

van der Wurp, Hendrik ^{[1
,26
]}

Dodel, Richard ^{[1
,5
]}

Jessen, Frank ^{[2
,3
,27
]}

机构：

[1] Univ Duisburg Essen, Ctr Translat Neurol & Behav Res, Dept Geriatr Med, Duisburg, Germany

[2] Univ Hosp Cologne, Med Fac, Dept Psychiat, Kerpener Str 62, D-50924 Cologne, Germany

[3] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[4] Univ Bonn, Dept Neurol, Bonn, Germany

[5] Philipps Univ Marburg, Dept Neurol, Marburg, Germany

[6] Georg August Univ, Univ Med Ctr Goettingen UMG, Dept Psychiat & Psychotherapy, Gottingen, Germany

[7] Ludwig Maximilians Univ LMU, Klinikum Univ Munchen, Inst Stroke & Dementia Res, Munich, Germany

[8] German Ctr Neurodegenerat Dis DZNE, Munich, Germany

[9] Landeskrankenhaus AoR, Ctr Mental Hlth Old Age, Mainz, Germany

[10] Heidelberg Univ, Zent Inst Seel Gesundheit Mannheim, Dept Geriatr Psychiat, Mannheim, Germany

[11] Univ Cologne, Fac Med, Inst Med Stat & Computat Biol, Cologne, Germany

[12] Univ Bern, Univ Hosp Old Age Psychiat, Bern, Switzerland

[13] German Ctr Neurodegenerat Dis DZNE, Berlin, Germany

[14] Charite, Dept Psychiat, Berlin, Germany

[15] Friedrich Alexander Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, Erlangen, Germany

[16] German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany

[17] Univ Tubingen, Hertie Inst Clin Brain Res, Sect Dementia Res, Tubingen, Germany

[18] Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany

[19] Charite, Dept Neuropsychiat, Berlin, Germany

[20] Berlin Inst Hlth, Berlin, Germany

[21] Univ Bonn, Klin Neurodegenerat Erkrankungen & Gerontopsychia, Bonn, Germany

[22] German Ctr Neurodegenerat Dis DZNE, Rostock, Germany

[23] Univ Hosp Rostock, Dept Psychosomat Med, Rostock, Germany

[24] Ulm Univ Hosp, Dept Neurol, Ulm, Germany

[25] German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany

[26] TU Dortmund Univ, Dept Stat, Dortmund, Germany

[27] Univ Cologne, Excellence Cluster Cellular Stress Responses Agin, Cologne, Germany

来源：

ALZHEIMERS & DEMENTIA | 2023年 / 19卷 / 07期

关键词：

Alzheimer's disease; apathy; cost of illness; dementia; economics; resource use; NEUROPSYCHIATRIC SYMPTOMS; DEMENTIA; CARE; PREVALENCE; INVENTORY; GERMANY; TRIALS; MODELS; SCALE;

D O I：

10.1002/alz.12915

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BackgroundApathy is the most frequent neuropsychiatric symptom in patients with dementia of the Alzheimer's type (DAT). We analyzed the influence of apathy on the resource use of DAT patients and their caregivers. MethodsIncluded were baseline data of 107 DAT patients from a randomized clinical trial on apathy treatment. The Resource Utilization in Dementia (RUD) instrument assessed costs over a 1-month period prior to baseline. Cost predictors were determined via a least absolute shrinkage and selection operator (LASSO). ResultsOn average, total monthly costs were euro3070, of which euro2711 accounted for caregivers' and euro359 for patients' costs. An increase of one point in the Apathy Evaluation Scale resulted in a 4.1% increase in total costs. DiscussionApathy is a significant cost driving factor for total costs in mild to moderate DAT. Effective treatment of apathy might be associated with reduced overall costs in DAT.

引用

页码：2853 / 2864

页数：12

共 50 条

[31] Measuring Apathy in Alzheimer's Disease in the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2): A Comparison of Instruments
Lanctot, Krista L.
Scherer, Roberta W.
Li, Abby
Vieira, Danielle
Coulibaly, Hamadou
Rosenberg, Paul B.
Herrmann, Nathan
Lerner, Alan J.
Padala, Prasad R.
Brawman-Mintzer, Olga
van Dyck, Chris H.
Porsteinsson, Anton P.
Craft, Suzanne
Levey, Allan
Burke, William J.
Mintzer, Jacobo E.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2021, 29 (01) : 81 - 89
[32] Factors Associated with Apathy in Alzheimer's Disease: A Cross-Sectional Analysis of the Texas Alzheimer's Research and Care Consortium (TARCC) Study
Teixeira, Antonio L.
Salem, Haitham
Martins, Lais B.
Gonzales, Mitzi M.
Seshadri, Sudha
Suchting, Robert
JOURNAL OF ALZHEIMERS DISEASE, 2022, 86 (01) : 403 - 411
[33] Apathy and Depression in Mild Alzheimer's Disease: A Cross-Sectional Study Using Diagnostic Criteria
Benoit, Michel
Berrut, Gilles
Doussaint, Johanna
Bakchine, Serge
Bonin-Guillaume, Sylvie
Fremont, Patrick
Gallarda, Thierry
Krolak-Salmon, Pierre
Marquet, Thierry
Mekies, Claude
Sellal, Francois
Schuck, Stephane
David, Renaud
Robert, Philippe
JOURNAL OF ALZHEIMERS DISEASE, 2012, 31 (02) : 325 - 334
[34] Unmet Needs in Pharmacological Treatment of Apathy in Alzheimer's Disease: A Systematic Review
Theleritis, Christos G.
Siarkos, Kostas T.
Politis, Antonios M.
FRONTIERS IN PHARMACOLOGY, 2019, 10
[35] Risk factors for apathy in Alzheimer's disease: A systematic review of longitudinal evidence
Azocar, Ignacia
Rapaport, Penny
Burton, Alexandra
Meisel, Georgia
Orgeta, Vasiliki
AGEING RESEARCH REVIEWS, 2022, 79
[36] Apathy in Alzheimer's disease
Teixeira, Antonio Lucio, Jr.
Caramelli, Paulo
REVISTA BRASILEIRA DE PSIQUIATRIA, 2006, 28 (03) : 238 - 241
[37] The prevalence, clinical correlates and treatment of apathy in Alzheimer's disease
Starkstein, Sergio E.
Jorge, Ricardo
Mizrahi, Romina
EUROPEAN JOURNAL OF PSYCHIATRY, 2006, 20 (02) : 96 - 106
[38] Epidemiology and Management of Apathy in Patients with Alzheimer’s Disease
Romina Mizrahi
Sergio E. Starkstein
Drugs & Aging, 2007, 24 : 547 - 554
[39] Apathy in frontotemporal dementia and Alzheimer's disease: are there distinct profiles?
Derouesne, Christian
Lacomblez, Lucette
Fiori, Nicole
Gely-Nargeot, Marie-Christine
Bungener, Catherine
GERIATRIE ET PSYCHOLOGIE NEUROPSYCHIATRIE DE VIEILLISSEMENT, 2012, 10 (01): : 106 - 114
[40] Cost of Patients with Alzheimer's Disease in Spain According to Disease Severity
Maldonado, Laura Gomez
de Mora-Figueroa, Ricardo
Lopez-Angarita, Angelica
Maravilla-Herrera, Paulina
Merino, Maria
PHARMACOECONOMICS-OPEN, 2024, 8 (01) : 103 - 114

← 1 2 3 4 5 →