Apathy in patients with Alzheimer's disease is a cost-driving factor

被引：5

作者：

Kruse, Christopher ^{[1
]}

Maier, Franziska ^{[2
]}

Spottke, Annika ^{[3
,4
]}

Bach, Jan-Philipp ^{[5
]}

Bartels, Claudia ^{[6
]}

Buerger, Katharina ^{[7
,8
]}

Fellgiebel, Andreas ^{[9
]}

Fliessbach, Klaus ^{[3
]}

Frolich, Lutz ^{[10
]}

Hausner, Lucrezia ^{[11
]}

Hellmich, Martin ^{[11
]}

Kloppel, Stefan ^{[12
]}

Klostermann, Arne ^{[13
,14
]}

Kornhuber, Johannes ^{[15
]}

Laske, Christoph ^{[16
,17
,18
]}

Peters, Oliver ^{[13
,14
]}

Priller, Josef ^{[13
,19
,20
]}

Richter-Schmidinger, Tanja ^{[15
]}

Schneider, Anja ^{[3
,21
]}

Shah-Hosseini, Kija ^{[11
]}

Teipel, Stefan ^{[22
,23
]}

von Arnim, Christine A. F. ^{[24
]}

Wiltfang, Jens ^{[6
,25
]}

van der Wurp, Hendrik ^{[1
,26
]}

Dodel, Richard ^{[1
,5
]}

Jessen, Frank ^{[2
,3
,27
]}

机构：

[1] Univ Duisburg Essen, Ctr Translat Neurol & Behav Res, Dept Geriatr Med, Duisburg, Germany

[2] Univ Hosp Cologne, Med Fac, Dept Psychiat, Kerpener Str 62, D-50924 Cologne, Germany

[3] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[4] Univ Bonn, Dept Neurol, Bonn, Germany

[5] Philipps Univ Marburg, Dept Neurol, Marburg, Germany

[6] Georg August Univ, Univ Med Ctr Goettingen UMG, Dept Psychiat & Psychotherapy, Gottingen, Germany

[7] Ludwig Maximilians Univ LMU, Klinikum Univ Munchen, Inst Stroke & Dementia Res, Munich, Germany

[8] German Ctr Neurodegenerat Dis DZNE, Munich, Germany

[9] Landeskrankenhaus AoR, Ctr Mental Hlth Old Age, Mainz, Germany

[10] Heidelberg Univ, Zent Inst Seel Gesundheit Mannheim, Dept Geriatr Psychiat, Mannheim, Germany

[11] Univ Cologne, Fac Med, Inst Med Stat & Computat Biol, Cologne, Germany

[12] Univ Bern, Univ Hosp Old Age Psychiat, Bern, Switzerland

[13] German Ctr Neurodegenerat Dis DZNE, Berlin, Germany

[14] Charite, Dept Psychiat, Berlin, Germany

[15] Friedrich Alexander Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, Erlangen, Germany

[16] German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany

[17] Univ Tubingen, Hertie Inst Clin Brain Res, Sect Dementia Res, Tubingen, Germany

[18] Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany

[19] Charite, Dept Neuropsychiat, Berlin, Germany

[20] Berlin Inst Hlth, Berlin, Germany

[21] Univ Bonn, Klin Neurodegenerat Erkrankungen & Gerontopsychia, Bonn, Germany

[22] German Ctr Neurodegenerat Dis DZNE, Rostock, Germany

[23] Univ Hosp Rostock, Dept Psychosomat Med, Rostock, Germany

[24] Ulm Univ Hosp, Dept Neurol, Ulm, Germany

[25] German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany

[26] TU Dortmund Univ, Dept Stat, Dortmund, Germany

[27] Univ Cologne, Excellence Cluster Cellular Stress Responses Agin, Cologne, Germany

来源：

ALZHEIMERS & DEMENTIA | 2023年 / 19卷 / 07期

关键词：

Alzheimer's disease; apathy; cost of illness; dementia; economics; resource use; NEUROPSYCHIATRIC SYMPTOMS; DEMENTIA; CARE; PREVALENCE; INVENTORY; GERMANY; TRIALS; MODELS; SCALE;

D O I：

10.1002/alz.12915

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BackgroundApathy is the most frequent neuropsychiatric symptom in patients with dementia of the Alzheimer's type (DAT). We analyzed the influence of apathy on the resource use of DAT patients and their caregivers. MethodsIncluded were baseline data of 107 DAT patients from a randomized clinical trial on apathy treatment. The Resource Utilization in Dementia (RUD) instrument assessed costs over a 1-month period prior to baseline. Cost predictors were determined via a least absolute shrinkage and selection operator (LASSO). ResultsOn average, total monthly costs were euro3070, of which euro2711 accounted for caregivers' and euro359 for patients' costs. An increase of one point in the Apathy Evaluation Scale resulted in a 4.1% increase in total costs. DiscussionApathy is a significant cost driving factor for total costs in mild to moderate DAT. Effective treatment of apathy might be associated with reduced overall costs in DAT.

引用

页码：2853 / 2864

页数：12

共 50 条

[21] Apathy Treatment in Alzheimer's Disease: Interim Results of the ASCOMALVA Trial
Rea, Raffaele
Carotenuto, Anna
Traini, Enea
Fasanaro, Angiola Maria
Manzo, Valentino
Amenta, Francesco
JOURNAL OF ALZHEIMERS DISEASE, 2015, 48 (02) : 377 - 383
[22] Emerging therapies for treatment of agitation, psychosis, or apathy in Alzheimer's disease
Wang, Hui Jue
Chinna-Meyyappan, Arun
Feldman, Oriel J.
Lanctot, Krista L.
EXPERT OPINION ON EMERGING DRUGS, 2024, 29 (03) : 289 - 303
[23] Awareness, apathy, and depression in Alzheimer's disease and mild cognitive impairment
Jacus, Jean-Pierre
BRAIN AND BEHAVIOR, 2017, 7 (04):
[24] The Effect of Apathy and Depressive Syndromes on Functional Outcomes in Alzheimer's Disease
Njomboro, Progress
Lekhutlile, Tlholego
JOURNAL OF ALZHEIMERS DISEASE, 2024, 98 (02) : 579 - 591
[25] Relationship between Apathy and Sleep Disturbance in Mild and Moderate Alzheimer's Disease: An Actigraphic Study
Mulin, Emmanuel
Zeitzer, Jamie M.
Friedman, Leah
Le Duff, Franck
Yesavage, Jerome
Robert, Philippe H.
David, Renaud
JOURNAL OF ALZHEIMERS DISEASE, 2011, 25 (01) : 85 - 91
[26] Apathy Diagnosis, Assessment, and Treatment in Alzheimer's Disease
Robert, Philippe H.
Mulin, Emmanuel
Mallea, Patrick
David, Renaud
CNS NEUROSCIENCE & THERAPEUTICS, 2010, 16 (05) : 263 - 271
[27] Apathy Associated with Alzheimer's Disease
Wu, Dan
Zhang, Bo
Chang, Yajuan
Huang, Shuming
CURRENT ALZHEIMER RESEARCH, 2024, 21 (08) : 527 - 537
[28] The Apathy Inventory: assessment of apathy and awareness in Alzheimer's disease, Parkinson's disease and mild cognitive impairment
Robert, PH
Clairet, S
Benoit, M
Koutaich, J
Bertogliati, C
Tible, O
Caci, H
Borg, M
Brocker, P
Bedoucha, P
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2002, 17 (12) : 1099 - 1105
[29] Treating apathy in Alzheimer's disease
Boyle, PA
Malloy, PF
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2004, 17 (1-2) : 91 - 99
[30] Apathy and anxiety are early markers of Alzheimer's disease
Johansson, Maurits
Stomrud, Erik
Lindberg, Olof
Westman, Eric
Johansson, Per Marten
van Westen, Danielle
Mattsson, Niklas
Hansson, Oskar
NEUROBIOLOGY OF AGING, 2020, 85 : 74 - 82

← 1 2 3 4 5 →