Concordance and Discordance Between Patient-reported Remission, Patient-reported Outcomes, and Physician Global Assessment

被引：7

作者：

Kamp, Kendra J. ^{[1
]}

Hawes, Stephen E. ^{[1
]}

Tse, Chung Sang ^{[2
]}

Singh, Siddharth ^{[2
]}

Dang, Nhu ^{[3
]}

Oberai, Ridhima ^{[4
]}

Weaver, S. Alandra ^{[4
]}

Melmed, Gil Y. ^{[5
]}

Siegel, Corey A. ^{[6
]}

van Deen, Welmoed K. ^{[7
]}

机构：

[1] Univ Washington, Seattle, WA 98195 USA

[2] Univ Calif San Diego, San Diego, CA 92103 USA

[3] Brown Univ, Providence, RI 02912 USA

[4] Crohns & Colitis Fdn, New York, NY USA

[5] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA

[6] Dartmouth Hitchcock Med Ctr, Hanover, NH USA

[7] Erasmus Sch Hlth Policy & Management, Rotterdam, Netherlands

来源：

INFLAMMATORY BOWEL DISEASES | 2023年 / 29卷 / 08期

基金：

美国国家卫生研究院;

关键词：

inflammatory bowel disease; patient-reported outcomes; remission; ULCERATIVE-COLITIS; DISEASE-ACTIVITY; CROHNS-DISEASE; CARE;

D O I：

10.1093/ibd/izac206

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Lay Summary Discordance between patients' self-reported remission and remission defined based on patient-reported outcomes was observed in 31% of Crohn's disease visits and 21% of ulcerative colitis visits. Disease duration and health confidence were associated with discordance. Background Although validated patient-reported outcome (PRO) measurements can categorize patients with inflammatory bowel disease (IBD) into clinical remission or active disease, patients may have different definitions of remission. The purpose of this study was to compare patient-defined remission to remission based on PRO measures and physician global assessment (PGA) and to understand the clinical and demographic factors associated with disagreements. Methods We retrospectively analyzed 3257 de-identified surveys from 2004 IBD patients who consented to participate in the Crohn's and Colitis Foundation's IBD Qorus Learning Health System between September 2019 and February 2021. We used logistic regression models with generalized estimating equations to analyze the clinical and demographic factors (eg, age, disease duration, health confidence) associated with discordance between patient-defined remission (yes/no) and PRO-defined remission for ulcerative colitis (UC; PRO2: stool frequency, rectal bleeding) and Crohn's disease (CD; PRO-3: average number of liquid stools, abdominal pain, well-being). Results Among patients with UC, overall concordance was 79% between patient self-report and PRO2-defined remission and 49% between patient self-report and PGA-defined remission. Among patients with CD, overall concordance was 69% between patient self-report and PRO3-defined remission and 54% between patient self-report and PGA-defined remission. Patients in PRO-defined remission were more likely to report active disease if they had IBD Conclusion Discordance exists between how remission is defined by patients, PRO measures, and PGA.

引用

页码：1255 / 1262

页数：8

共 36 条

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