Smartphone bioelectronic drug with visual colorimetric sensor and bulk nanoencapsulation optogenetic bacteria for chronic kidney disease theragnostics

被引：17

作者：

Cui, Meihui ^{[1
]}

Ling, Wei ^{[2
]}

Zhang, Lili ^{[1
]}

Li, Yayang ^{[3
]}

Liu, Jing ^{[1
]}

Sun, Tao ^{[4
,5
]}

Ma, Binglin ^{[1
]}

Lu, Shenjunjie ^{[1
]}

Pan, Huizhuo ^{[1
]}

Pang, Gaoju ^{[1
]}

Zhang, Yingying ^{[1
]}

Zhang, Shufang ^{[3
]}

Huang, Xian ^{[2
]}

Zhao, Peiqi ^{[6
]}

Liu, Duo ^{[1
,7
,8
]}

Wang, Hanjie ^{[1
]}

机构：

[1] Tianjin Univ, Sch Life Sci, Tianjin 300072, Peoples R China

[2] Tianjin Univ, Dept Biomed Engn, Tianjin 300072, Peoples R China

[3] Tianjin Univ, Sch Elect & Informat Engn, Tianjin 300072, Peoples R China

[4] Tianjin Univ, Ctr Biosafety Res & Strategy, Tianjin 300072, Peoples R China

[5] Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300350, Peoples R China

[6] Tianjin Med Univ, Tianjins Clin Res Ctr Canc, Dept Lymphoma,Tianjin Med Univ Canc Inst & Hosp, Key Lab Canc Prevent & Therapy,Natl Clin Res Ctr, Tianjin 300203, Peoples R China

[7] Tianjin Univ, Frontier Sci Ctr Synthet Biol, Minist Educ, Tianjin 301799, Peoples R China

[8] Tianjin Univ, Key Lab Syst Bioengn, Minist Educ, Tianjin 301799, Peoples R China

来源：

CHEMICAL ENGINEERING JOURNAL | 2023年 / 451卷

基金：

中国国家自然科学基金;

关键词：

Chronic kidney disease; Optogenetic bacteria; Drug delivery; Bulk nanoencapsulation; Colorimetric sensor;

D O I：

10.1016/j.cej.2022.138812

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Point-of-care testing (POCT) has been widely employed for chronic disease diagnosis due to its portable testing modalities and fast medical decisions. However, conventional POCT techniques lack the means of rapid and precise treatment, deviating from the requirement of an integrated theragnostics system for home diagnosis and personalized therapy. Here, we present a smartphone-controlled, system-level bioelectronic drug with pro-grammable point-of-care theragnostics (POCTH) for chronic kidney disease monitoring. The system features a urine-based colorimetric sensor for pathological quantification and engineered bacteria that can generate tar-geted immune regulators (IL-10) for disease modulation, allowing real-time, at-home chronic disease diagnosis and treatment. Customized smartphone applications have been developed for image capture, colorimetric analysis, and wireless transmission. Besides, a flexible optoelectronic device has also been fabricated for conformal integration with rats and wireless modulation of optogenetic bacteria. The system leads to sophisti-cated applications in physiological monitoring and personalized diagnosis of chronic diseases.

引用

页数：12

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