Emerging Roles of Microglia in Blood-Brain Barrier Integrity in Aging and Neurodegeneration

被引：6

作者：

Zhang, Simeng ^{[1
]}

Meng, Rui ^{[1
]}

Jiang, Muzhou ^{[1
,2
]}

Qing, Hong ^{[1
]}

Ni, Junjun ^{[1
]}

机构：

[1] Beijing Inst Technol, Sch Life Sci, Dept Biol, Key Lab Mol Med & Biotherapy, Beijing 100081, Peoples R China

[2] China Med Univ, Sch & Hosp Stomatol, Dept Periodont, Liaoning Prov Key Lab Oral Dis, Shenyang 110002, Peoples R China

来源：

CURRENT NEUROPHARMACOLOGY | 2024年 / 22卷 / 07期

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

Microglia; neuroinflammation; blood-brain barrier; neurovascular unit; aging; neurodegeneration; MONOCYTE CHEMOATTRACTANT PROTEIN-1; CENTRAL-NERVOUS-SYSTEM; TUMOR-NECROSIS-FACTOR; ENDOTHELIAL GROWTH-FACTOR; TIGHT JUNCTION; FACTOR-ALPHA; TNF-ALPHA; EXPRESSION; ASTROCYTES; RECEPTOR;

D O I：

10.2174/1570159X21666230203103910

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The blood-brain barrier (BBB) is a highly selective interface between the blood and the brain parenchyma. It plays an essential role in maintaining a specialized environment for central nervous system function and homeostasis. The BBB disrupts with age, which contributes to the development of many age-related disorders due to central and peripheral toxic factors or BBB dysfunction. Microglia, the resident innate immune cells of the brain, have recently been explored for their ability to directly and indirectly regulate the integrity of the BBB. This review will focus on the current understanding of the molecular mechanisms utilized by microglia to regulate BBB integrity and how this becomes disrupted in aging and age-associated diseases. We will also discuss the rationale for considering microglia as a therapeutic target to prevent or slow down neurodegeneration.

引用

页码：1189 / 1204

页数：16

共 129 条

[1] Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein [J].