Cardiac effects of myoregulin in ischemia-reperfusion

被引：1
|
作者：
Appleby, Sarah [1 ,5 ]
Aitken-Buck, Hamish M. [2 ]
Holdaway, Mark S. [1 ]
Byers, Mathew S. [1 ]
Frampton, Chris M. [1 ]
Paton, Louise N. [1 ]
Richards, A. Mark [1 ,3 ,4 ]
Lamberts, Regis R. [2 ]
Pemberton, Christopher J. [1 ]
机构：
[1] Univ Otago, Christchurch Heart Inst, 2 Riccarton Ave, Christchurch 8011, New Zealand
[2] Univ Otago, Dept Physiol, HeartOtago, 270 Great King St, Dunedin 9016, New Zealand
[3] Te Whatu Ora Waitaha, Dept Cardiol, 2 Riccarton Ave, Christchurch 8011, New Zealand
[4] Natl Univ Singapore, Cardiovasc Res Inst, 1E Kent Ridge Rd, Singapore, Singapore
[5] Univ Otago, Christchurch Heart Inst, Dept Med, 2 Riccarton Ave, Christchurch 8011, New Zealand
来源：
PEPTIDES | 2024年 / 174卷
关键词：
Myoregulin; Hemodynamics; Langendorff isolated rat heart; Gene expression; Ischemia/reperfusion; SERCA; SARCOPLASMIC-RETICULUM; PHOSPHOLAMBAN PHOSPHORYLATION; GENE-EXPRESSION; CALCIUM-UPTAKE; MUSCLE; RNA; INJURY; HEART;
D O I：
10.1016/j.peptides.2024.171156
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Myoregulin is a recently discovered micropeptide that controls calcium levels by inhibiting the intracellular calcium pump sarco-endoplasmic reticulum Ca2+-ATPase (SERCA). Keeping calcium levels balanced in the heart is essential for normal heart functioning, thus myoregulin has the potential to be a crucial regulator of cardiac muscle performance by reducing the rate of intracellular Ca2+ uptake. We provide the first report of myoregulin mRNA expression in human heart tissue, absence of expression in human plasma, and the effects of myoregulin on cardiac hemodynamics in an ex vivo Langendorff isolated rat heart model of ischemia/reperfusion. In this preliminary study, myoregulin provided a cardio-protective effect, as assessed by preservation of left ventricular contractility and relaxation, during ischemia/reperfusion. This study provides the foundation for future research in this area.
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页数：7
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