Advancing pathogen genomics in resource-limited settings

被引：12

作者：

Pronyk, Paul Michael ^{[1
]}

de Alwis, Ruklanthi ^{[1
,2
]}

Rockett, Rebecca ^{[3
,4
]}

Basile, Kerri ^{[5
]}

Boucher, Yann Felix ^{[6
,7
,8
,9
]}

Pang, Vincent ^{[1
]}

Sessions, October ^{[3
]}

Getchell, Marya ^{[1
]}

Golubchik, Tanya ^{[3
,4
,10
]}

Lam, Connie ^{[3
,4
]}

Lin, Raymond ^{[11
]}

Mak, Tze-Minn ^{[12
]}

Marais, Ben ^{[3
]}

Ong, Rick Twee-Hee ^{[6
]}

Clapham, Hannah Eleanor ^{[6
]}

Wang, Linfa ^{[2
,13
]}

Cahyorini, Yorin ^{[14
]}

Polotan, Francisco Gerardo M. ^{[15
]}

Rukminiati, Yuni ^{[14
]}

Sim, Eby ^{[3
,4
]}

Suster, Carl ^{[3
]}

Smith, Gavin J. D. ^{[2
]}

Sintchenko, Vitali ^{[3
,4
,5
]}

机构：

[1] Duke NUS Med Sch, Ctr Outbreak Preparedness, Singapore 169857, Singapore

[2] Duke NUS Med Sch, Programme Emerging Infect Dis, Singapore 169857, Singapore

[3] Univ Sydney, Sydney Infect Dis Inst, Camperdown, NSW 2006, Australia

[4] Westmead Hosp, Ctr Infect Dis & Microbiol Publ Hlth, Westmead, NSW 2145, Australia

[5] NSW Hlth Pathol, Inst Clin Pathol & Med Res, Ctr Infect Dis & Microbiol Lab Serv, Westmead, NSW 2145, Australia

[6] Natl Univ Singapore, Natl Univ Hlth Syst, Saw Swee Hock Sch Publ Hlth, Singapore 117549, Singapore

[7] Natl Univ Singapore, Natl Univ Hlth Syst, Yong Loo Lin Sch Med, Infect Dis Translat Res Programme, Singapore, Singapore

[8] Natl Univ Singapore, Singapore Ctr Environm Life Sci Engn, Singapore, Singapore

[9] Nanyang Technol Univ, Singapore 639798, Singapore

[10] Univ Oxford, Big Data Inst, Nuffield Dept Med, Oxford OX3 7LF, England

[11] Natl Ctr Infect Dis, Natl Publ Hlth Lab, Singapore 308442, Singapore

[12] Agcy Sci Technol & Res, Bioinformat Inst, Singapore 138671, Singapore

[13] Minist Hlth, Programme Res Epidem Preparedness & Response PREPA, Singapore 169854, Singapore

[14] Hlth Policy Agcy, Ctr Hlth Resilience & Resource Policy, Jakarta, Indonesia

[15] Res Inst Trop Med, Mol Biol Lab, Muntinlupa 1781, Metro Manila, Philippines

来源：

CELL GENOMICS | 2023年 / 3卷 / 12期

关键词：

RESPIRATORY VIRUSES; INSIGHTS; HEALTH;

D O I：

10.1016/j.xgen.2023.100443

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Genomic sequencing has emerged as a powerful tool to enhance early pathogen detection and characterization with implications for public health and clinical decision making. Although widely available in developed countries, the application of pathogen genomics among low-resource, high-disease burden settings remains at an early stage. In these contexts, tailored approaches for integrating pathogen genomics within infectious disease control programs will be essential to optimize cost efficiency and public health impact. We propose a framework for embedding pathogen genomics within national surveillance plans across a spectrum of surveillance and laboratory capacities. We adopt a public health approach to genomics and examine its application to high-priority diseases relevant in resource-limited settings. For each grouping, we assess the value proposition for genomics to inform public health and clinical decision-making, alongside its contribution toward research and development of novel diagnostics, therapeutics, and vaccines.

引用

页数：14

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