Hydrogel-Based Growth Factor Delivery Platforms: Strategies and Recent Advances

被引:161
作者
Shan, Bai-Hui [1 ]
Wu, Fu-Gen [1 ]
机构
[1] Southeast Univ, Jiangsu Key Lab Biomat & Devices, Sch Biol Sci & Med Engn, State Key Lab Digital Med Engn, 2 Sipailou Rd, Nanjing 210096, Peoples R China
基金
中国国家自然科学基金;
关键词
drug delivery; growth factors; hydrogels; regeneration medicines; tissue engineering; PLATELET-RICH PLASMA; ASSEMBLING PEPTIDE HYDROGEL; HYALURONIC-ACID HYDROGEL; ACOUSTICALLY-RESPONSIVE SCAFFOLDS; STEM-CELLS; INJECTABLE HYDROGEL; SUSTAINED-RELEASE; BONE REGENERATION; IN-VITRO; COMPOSITE HYDROGELS;
D O I
10.1002/adma.202210707
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Growth factors play a crucial role in regulating a broad variety of biological processes and are regarded as powerful therapeutic agents in tissue engineering and regenerative medicine in the past decades. However, their application is limited by their short half-lives and potential side effects in physiological environments. Hydrogels are identified as having the promising potential to prolong the half-lives of growth factors and mitigate their adverse effects by restricting them within the matrix to reduce their rapid proteolysis, burst release, and unwanted diffusion. This review discusses recent progress in the development of growth factor-containing hydrogels for various biomedical applications, including wound healing, brain tissue repair, cartilage and bone regeneration, and spinal cord injury repair. In addition, the review introduces strategies for optimizing growth factor release including affinity-based delivery, carrier-assisted delivery, stimuli-responsive delivery, spatial structure-based delivery, and cellular system-based delivery. Finally, the review presents current limitations and future research directions for growth factor-delivering hydrogels. A comprehensive review on the progress of hydrogel-based growth factor delivery systems for biomedical applications and the strategies utilized for growth factor delivery optimization is presented, with an emphasis on the ways the hydrogels facilitate the delivery and improve the therapeutic efficacy of growth factors. The current limitations and future research directions in this field are also discussed.image
引用
收藏
页数:40
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