Heterogeneity and individualized treatment of microenvironment in glioblastoma (Review)

被引：3

作者：

Kang, Wei ^{[1
]}

Mo, Zhixiao ^{[2
]}

Li, Wenshan ^{[1
,3
]}

Ma, Haifeng ^{[1
]}

Zhang, Qiang ^{[1
,4
]}

机构：

[1] Qinghai Prov Peoples Hosp, Dept Neurosurg, Xining 810001, Qinghai, Peoples R China

[2] Qinghai Cardiocerebrovasc Hosp, Dept Neurosurg, Xining 810099, Qinghai, Peoples R China

[3] Lanzhou Univ, Hosp 2, Dept Neurosurg, Key Lab Neurol Gansu Prov, Lanzhou 730030, Gansu, Peoples R China

[4] Qinghai Prov Peoples Hosp, Dept Neurosurg, 2 Gonghe Rd, Xining 810001, Qinghai, Peoples R China

来源：

ONCOLOGY REPORTS | 2023年 / 50卷 / 06期

关键词：

glioblastoma; heterogeneity of immune microenviron-ment; metabolism; immune escape; individualized; RECURRENT GLIOBLASTOMA; TUMOR HETEROGENEITY; CLONAL EVOLUTION; DIGITAL PCR; BEVACIZUMAB; THERAPY; TEMOZOLOMIDE; COMBINATION; CELLS;

D O I：

10.3892/or.2023.8654

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The heterogeneity of glioblastoma can suppress immune cell function and lead to immune evasion, which presents a challenge in developing effective molecular therapies for tumor cells. However, the study of tumor immune heterogeneity holds great potential for clinical immunotherapy. Liquid biopsy is a useful tool for accurately monitoring dynamic changes in tumor immune heterogeneity and the tumor microenvironment. This paper explores the heterogeneity of glioblastoma and the immune microenvironment, providing a therapeutic basis for individualized treatment. Using liquid biopsy technology as a new diagnostic method, innovative treatment strategies may be implemented for patients with glioblastoma to improve their outcomes.

引用

页数：9

共 71 条

[1] Geospatial immune variability illuminates differential evolution of lung adenocarcinoma [J].

AbdulJabbar, Khalid ;

Raza, Shan E. Ahmed ;

Rosenthal, Rachel ;

Jamal-Hanjani, Mariam ;

Veeriah, Selvaraju ;

Akarca, Ayse ;

Lund, Tom ;

Moore, David A. ;

Salgado, Roberto ;

Al Bakir, Maise ;

Zapata, Luis ;

Hiley, Crispin T. ;

Officer, Leah ;

Sereno, Marco ;

Smith, Claire Rachel ;

Loi, Sherene ;

Hackshaw, Allan ;

Marafioti, Teresa ;

Quezada, Sergio A. ;

McGranahan, Nicholas ;

Le Quesne, John ;

Swanton, Charles ;

Yuan, Yinyin .

NATURE MEDICINE, 2020, 26 (07) :1054-+

[2] Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment [J].

Azizi, Elham ;

Carr, Ambrose J. ;

Plitas, George ;

Cornish, Andrew E. ;

Konopacki, Catherine ;

Prabhakaran, Sandhya ;

Nainys, Juozas ;

Wu, Kenmin ;

Kiseliovas, Vaidotas ;

Setty, Manu ;

Choi, Kristy ;

Fromme, Rachel M. ;

Phuong Dao ;

McKenney, Peter T. ;

Wasti, Ruby C. ;

Kadaveru, Krishna ;

Mazutis, Linas ;

Rudensky, Alexander Y. ;

Pe'er, Dana .

CELL, 2018, 174 (05) :1293-+

[3] Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy [J].

Bastola, Soniya ;

Pavlyukov, Marat S. ;

Yamashita, Daisuke ;

Ghosh, Sadashib ;

Cho, Heejin ;

Kagaya, Noritaka ;

Zhang, Zhuo ;

Minata, Mutsuko ;

Lee, Yeri ;

Sadahiro, Hirokazu ;

Yamaguchi, Shinobu ;

Komarova, Svetlana ;

Yang, Eddy ;

Markert, James ;

Nabors, Louis B. ;

Bhat, Krishna ;

Lee, James ;

Chen, Qin ;

Crossman, David K. ;

Shin-Ya, Kazuo ;

Nam, Do-Hyun ;

Nakano, Ichiro .

NATURE COMMUNICATIONS, 2020, 11 (01)

[4] Transforming Growth Factor-β Signaling in Immunity and Cancer [J].

Batlle, Eduard ;

Massague, Joan .

IMMUNITY, 2019, 50 (04) :924-940

[5] Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression [J].

Bernard, Vincent ;

Semaan, Alexander ;

Huang, Jonathan ;

San Lucas, F. Anthony ;

Mulu, Feven C. ;

Stephens, Bret M. ;

Guerrero, Paola A. ;

Huang, Yanqing ;

Zhao, Jun ;

Kamyabi, Nabiollah ;

Sen, Subrata ;

Scheet, Paul A. ;

Taniguchi, Cullen M. ;

Kim, Michael P. ;

Tzeng, Ching-Wei ;

Katz, Matthew H. ;

Singhi, Aatur D. ;

Maitra, Anirban ;

Alvarez, Hector A. .

CLINICAL CANCER RESEARCH, 2019, 25 (07) :2194-2205

[6] Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies [J].

Bettegowda, Chetan ;

Sausen, Mark ;

Leary, Rebecca J. ;

Kinde, Isaac ;

Wang, Yuxuan ;

Agrawal, Nishant ;

Bartlett, Bjarne R. ;

Wang, Hao ;

Luber, Brandon ;

Alani, Rhoda M. ;

Antonarakis, Emmanuel S. ;

Azad, Nilofer S. ;

Bardelli, Alberto ;

Brem, Henry ;

Cameron, John L. ;

Lee, Clarence C. ;

Fecher, Leslie A. ;

Gallia, Gary L. ;

Gibbs, Peter ;

Le, Dung ;

Giuntoli, Robert L. ;

Goggins, Michael ;

Hogarty, Michael D. ;

Holdhoff, Matthias ;

Hong, Seung-Mo ;

Jiao, Yuchen ;

Juhl, Hartmut H. ;

Kim, Jenny J. ;

Siravegna, Giulia ;

Laheru, Daniel A. ;

Lauricella, Calogero ;

Lim, Michael ;

Lipson, Evan J. ;

Marie, Suely Kazue Nagahashi ;

Netto, George J. ;

Oliner, Kelly S. ;

Olivi, Alessandro ;

Olsson, Louise ;

Riggins, Gregory J. ;

Sartore-Bianchi, Andrea ;

Schmidt, Kerstin ;

Shih, Ie-Ming ;

Oba-Shinjo, Sueli Mieko ;

Siena, Salvatore ;

Theodorescu, Dan ;

Tie, Jeanne ;

Harkins, Timothy T. ;

Veronese, Silvio ;

Wang, Tian-Li ;

Weingart, Jon D. .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (224)

[7] Understanding the tumor immune microenvironment (TIME) for effective therapy [J].

Binnewies, Mikhail ;

Roberts, Edward W. ;

Kersten, Kelly ;

Chan, Vincent ;

Fearon, Douglas F. ;

Merad, Miriam ;

Coussens, Lisa M. ;

Gabrilovich, Dmitry I. ;

Ostrand-Rosenberg, Suzanne ;

Hedrick, Catherine C. ;

Vonderheide, Robert H. ;

Pittet, Mikael J. ;

Jain, Rakesh K. ;

Zou, Weiping ;

Howcroft, T. Kevin ;

Woodhouse, Elisa C. ;

Weinberg, Robert A. ;

Krummel, Matthew F. .

NATURE MEDICINE, 2018, 24 (05) :541-550

[8] Radiosurgery for Glioblastoma [J].

Bunevicius, Adomas ;

Sheehan, Jason P. .

NEUROSURGERY CLINICS OF NORTH AMERICA, 2021, 32 (01) :117-128

[9] Phase I/II study of sorafenib in combination with erlotinib for recurrent glioblastoma as part of a 3-arm sequential accrual clinical trial: NABTC 05-02 [J].

Chen, Huanwen ;

Kuhn, John ;

Lamborn, Kathleen R. ;

Abrey, Lauren E. ;

DeAngelis, Lisa M. ;

Lieberman, Frank ;

Robins, H. Ian ;

Chang, Susan M. ;

Yung, W. K. Alfred ;

Drappatz, Jan ;

Mehta, Minesh P. ;

Levin, Victor A. ;

Aldape, Kenneth ;

Dancey, Janet E. ;

Wright, John J. ;

Prados, Michael D. ;

Cloughesy, Timothy F. ;

Wen, Patrick Y. ;

Gilbert, Mark R. .

NEURO-ONCOLOGY ADVANCES, 2020, 2 (01)

[10] An Immune Atlas of Clear Cell Renal Cell Carcinoma [J].

Chevrier, Stephane ;

Levine, Jacob Harrison ;

Zanotelli, Vito Riccardo Tomaso ;

Silina, Karina ;

Schulz, Daniel ;

Bacac, Marina ;

Ries, Carola Hermine ;

Ailles, Laurie ;

Jewett, Michael Alexander Spencer ;

Moch, Holger ;

van den Broek, Maries ;

Beisel, Christian ;

Stadler, Michael Beda ;

Gedye, Craig ;

Reis, Bernhard ;

Pe'er, Dana ;

Bodenmiller, Bernd .

CELL, 2017, 169 (04) :736-749

← 1 2 3 4 5 6 7 8 →