Reordering and synchronization of electrical turbulence in cardiac tissue through global and partial optogenetical illumination

被引：4

作者：

Li, Teng-Chao ^{[1
,2
]}

Zhong, Wei ^{[2
]}

Ai, Bao-quan ^{[2
]}

Zhu, Wei-Jing ^{[3
]}

Li, Bing -Wei ^{[1
]}

V. Panfilov, Alexander ^{[4
,5
,6
]}

Dierckx, Hans ^{[7
,8
]}

机构：

[1] Hangzhou Normal Univ, Sch Phys, Hangzhou 311121, Peoples R China

[2] South China Normal Univ, Sch Phys & Telecommun Engn, Guangzhou 510006, Peoples R China

[3] Guangdong Polytech Normal Univ, Sch Photoelect Engn, Guangzhou 510665, Peoples R China

[4] Ural Fed Univ, Biomed Lab, Ekaterinburg 620002, Russia

[5] Univ Ghent, Dept Phys & Astron, B-9000 Ghent, Belgium

[6] IM Sechenov First Moscow State Med Univ, World Class Res Ctr Digital biodesign & personaliz, Moscow 119991, Russia

[7] Katholieke Univ Leuven, Dept Math, Campus Kortrijk Kulak,Etienne Sabbelaan 53 bus 765, B-8500 Kortrijk, Belgium

[8] Katholieke Univ Leuven, Inst Phys based Modeling Sil Hlth, iSi Hlth, Leuven, Belgium

来源：

PHYSICAL REVIEW E | 2023年 / 108卷 / 03期

基金：

中国国家自然科学基金;

关键词：

SPIRAL WAVES; VENTRICULAR-FIBRILLATION; PATTERN-FORMATION; MODEL; ORGANIZATION; PROPAGATION; MECHANISMS; DIFFUSION; EVOLUTION; BREAKUP;

D O I：

10.1103/PhysRevE.108.034218

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

Electrical turbulence in the heart is considered the culprit of cardiac disease, including the fatal ventricular fibrillation. Optogenetics is an emerging technology that has the capability to produce action potentials of cardiomyocytes to affect the electric wave propagation in cardiac tissue, thereby possessing the potential to control the turbulence, by shining a rotating spiral pattern onto the tissue. In this paper, we present a method to reorder and synchronize electrical turbulence through optogenetics. A generic two-variable reaction-diffusion model and a simplified three-variable ionic cardiac model are used. We discuss cases involving either global or partial illumination.

引用

页数：9

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