Familial Association of Granulomatosis With Polyangiitis: A Case-Based Review of Literature

被引：1
|
作者：
Farrukh, Larabe [1 ]
Mumtaz, Aqsa [2 ]
Sami, Faria [3 ]
Faraz, Maria [4 ]
Ngo, Khoa Richard [5 ]
机构：
[1] Albany Med Ctr, Internal Med, Albany, NY 12208 USA
[2] King Edward Med Univ, Internal Med, Lahore, Pakistan
[3] Allama Iqbal Med Coll, Internal Med, Lahore, Pakistan
[4] Albany Med Ctr, Pathol, Albany, NY USA
[5] Albany Med Ctr, Rheumatol, Albany, NY USA
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 06期
关键词：
granulomatosis with polyangiitis (gpa); familial disease; genetic syndromes; anca associated vasculitis; auto immune; WEGENERS-GRANULOMATOSIS; VASCULITIDES;
D O I：
10.7759/cureus.40786
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is a class of small vessel vasculitis that includes granulomatosis with polyangiitis (GPA), eosinophilic GPA (EGPA), and microscopic polyangiitis (MPA). Despite extensive research, the mechanisms behind AAV etiology remain obscure. The genetics of AAV is a complex area of investigation because of the rarity of familial cases. However, recent multi-center genome-wide association studies (GWAS) have greatly contributed to our understanding of the genetic basis of AAV. In this study, we report a rare occurrence of GPA in two Caucasian family members who presented with similar clinical symptoms and performed a comprehensive review to study the present literature available regarding the heritability of this disease.
引用
收藏
页数：8
相关论文
共 50 条
  • [31] Gingival hyperplasia as first sign of recurrence of granulomatosis with polyangiitis (Wegener's granulomatosis): case report and review of the literature
    Hanisch, Marcel
    Froehlich, Leopold F.
    Kleinheinz, Johannes
    BMC ORAL HEALTH, 2016, 17
  • [32] Granulomatosis with polyangiitis with breast involvement mimicking metastatic cancer: Case report and literature review
    Gadeyne, Laura
    Henckaerts, Liesbet
    Goffin, Karolien E.
    Gheysens, Olivier
    Lerut, Evelyne
    Roskams, Tania
    Blockmans, Daniel
    Floris, Giuseppe
    EUROPEAN JOURNAL OF RHEUMATOLOGY, 2020, 7 (01) : 41 - 43
  • [33] Gingival hyperplasia as first sign of recurrence of granulomatosis with polyangiitis (Wegener’s granulomatosis): case report and review of the literature
    Marcel Hanisch
    Leopold F. Fröhlich
    Johannes Kleinheinz
    BMC Oral Health, 17
  • [34] Granulomatosis with polyangiitis with lacrimal gland enlargement and pancreatic swelling: A case report and a literature review
    Kawajiri, Tetsuya
    Iwata, Shigeru
    Tanaka, Katsunori
    Sonoda, Takeru
    Nishikawa, Mizuki
    Iwamoto, Ryuta
    Takahashi, Yuichi
    Kojima, Fumiyoshi
    Fujii, Takao
    MODERN RHEUMATOLOGY CASE REPORTS, 2024, : 155 - 162
  • [35] Imatinib mesylate use in refractory eosinophilic granulomatosis with polyangiitis: a literature review and a case report
    Tatiana V. Beketova
    Mikhail Y. Volkov
    Evgeniy A. Naryshkin
    Tatiana M. Novoselova
    Evgeniy L. Nasonov
    Clinical Rheumatology, 2018, 37 : 1729 - 1735
  • [36] Calcified Amorphous Tumor and Granulomatosis with Polyangiitis-Case Report and Systematic Review of the Literature
    Suleiman, Mathieu N.
    Agaimy, Abbas
    Dewald, Oliver
    Kaemmerer-Suleiman, Ann-Sophie
    Mellert, Fritz
    Weyand, Michael
    Harig, Frank
    JOURNAL OF CLINICAL MEDICINE, 2025, 14 (01)
  • [37] Accessory left gastric artery aneurysms in granulomatosis with polyangiitis: a case report and literature review
    Tomosugi, Toshihide
    Takahashi, Takuji
    Kawase, Yoshihisa
    Yoshida, Koichi
    Hayashi, Shogo
    Sugiyama, Takefumi
    Shimizu, Mitsuya
    Shoka, Michita
    Sawaki, Kohichi
    Onishi, Eiji
    Hayashi, Naomi
    Matsushita, Hidenobu
    Okochi, Osamu
    NAGOYA JOURNAL OF MEDICAL SCIENCE, 2017, 79 (01): : 75 - 83
  • [38] Rituximab induction without maintenance for granulomatosis with polyangiitis and dialysis - Case report and literature review
    Kolitz, T.
    Tanay, A.
    Biro, A.
    Zandman-Goddard, G.
    BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY, 2018, 32 (04): : 535 - 540
  • [39] Limited granulomatosis with polyangiitis in children with idiopathic orbital inflammation: a case series and literature review
    Baca, Vicente
    Barragan-Garcia, Alejandro A.
    Garcia-Vega, Daphne
    Vazquez-Lara, Yolanda
    Siordia-Reyes, Georgina
    Yanez-Gutierrez, Lucelli
    RHEUMATOLOGY INTERNATIONAL, 2024, 44 (11) : 2679 - 2690
  • [40] Management of granulomatosis with polyangiitis complicated by intestinal perforation and pancytopenia: a case report and literature review
    Smiyan, Svitlana
    Dyadyk, Olena
    Kvasnitska, Oksana
    Makhovska, Olexandra
    Antiuk, Zhanna
    Bidovanets, Taras
    Komorovsky, Roman
    RHEUMATOLOGY INTERNATIONAL, 2024, 44 (07) : 1369 - 1379
12345