Prognostic factors for satellitosis or in-transit metastasis in cutaneous squamous cell carcinoma: A multicentric cohort study

被引:3
|
作者
Marti-Marti, Ignasi [1 ,18 ]
Podlipnik, Sebastian [1 ]
Canueto, Javier [2 ]
Ferrandiz-Pulido, Carla [3 ]
Deza, Gustavo [4 ]
Sanmartin, Onofre [5 ]
Jaka, Ane [6 ]
Bea-Ardebol, Sonia [7 ]
Botella-Estrada, Rafael [8 ]
Redondo, Pedro [9 ]
Turrion-Merino, Lucia [10 ]
Ruiz-Salas, Veronica [11 ]
Masferrer, Emili [12 ]
Yebenes, Mireia [13 ]
Sanchez-Schmidt, Julia-Maria [14 ]
Gracia-Darder, Ines [15 ]
Altemir-Vidal, Arcadi [16 ]
Aguayo-Ortiz, Rafael S. [17 ]
Becerril, Sara [2 ]
Bodet-Castillo, Domingo [3 ]
Leal, Lorena [4 ]
Fuente, Maria Jose [6 ]
Moreno-Arrones, Oscar Munoz [7 ]
Abril-Perez, Carlos [8 ]
Tomas-Velazquez, Alejandra [9 ]
Sandoval-Clavijo, Alejandra [1 ]
Toll, Agusti [1 ]
机构
[1] Univ Barcelona, Hosp Clin Barcelona, Dept Dermatol, Barcelona, Spain
[2] Complejo Asistencial Univ Salamanca, Dept Dermatol, Salamanca, Spain
[3] Hosp Univ Vall Dhebron, Dept Dermatol, Barcelona, Spain
[4] Hosp Mar, Dept Dermatol, Barcelona, Spain
[5] Inst Valenciano Oncologia, Dept Dermatol, Valencia, Spain
[6] Univ Autonoma Barcelona, Hosp Univ Germans Trias i Pujol, Dept Dermatol, Badalona, Spain
[7] Hosp Univ Ramon & Cajal, Dept Dermatol, Madrid, Spain
[8] Hosp Univ & Politecn La Fe, Dept Dermatol, Valencia, Spain
[9] Clin Univ Navarra, Dept Dermatol, Madrid, Spain
[10] Hosp Univ Puerta Hierro, Dept Dermatol, Majadahonda, Spain
[11] Hosp Santa Creu i St Pau, Dept Dermatol, Barcelona, Spain
[12] Hosp Univ Mutua Terrassa, Dept Dermatol, Terrassa, Spain
[13] Consorci Corporacio Sanitaia Parc Tauli, Dept Dermatol, Sabadell, Spain
[14] Hosp Gen Granollers, Dept Dermatol, Granollers, Spain
[15] Hosp Univ Son Espases, Dept Dermatol, Palma De Mallorca, Spain
[16] Hosp Univ Sagrat Cor, Dept Dermatol, Barcelona, Spain
[17] Hosp Arnau Vilanova, Dept Dermatol, Lleida, Spain
[18] Univ Barcelona, Hosp Clin Barcelona, Dept Dermatol, Carrer Villarroel 170, Barcelona 08036, Spain
关键词
in-transit metastasis; satellitosis; satellite lesions; squamous cell carcinoma; skin cancer;
D O I
10.1016/j.jaad.2023.02.048
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Satellitosis or in-transit metastasis (S-ITM) has clinical outcomes comparable to node-positivity in cutaneous squamous cell carcinoma (cSCC). There is a need to stratify the risk groups.Objective: To determine which prognostic factors of S-ITM confer an increased risk of relapse and cSCC-specificedeath.Methods: A retrospective, multicenter cohort study. Patients with cSCC developing S-ITM were included. Multivariate competing risk analysis evaluated which factors were associated with relapse and specific death.Results: Of a total of 111 patients with cSCC and S-ITM, 86 patients were included for analysis. An S-ITM size of $20 mm, >5 S-ITM lesions, and a primary tumor deep invasion was associated with an increased cumulative incidence of relapse (subhazard ratio [SHR]: 2.89 [95% CI, 1.44-5.83; P = .003], 2.32 [95% CI, 1.13-4.77; P = .021], and 2.863 [95% CI, 1.25-6.55; P = .013]), respectively. Several >5 S-ITM lesions were also associated with an increased probability of specific death (SHR: 3.48 [95% CI, 1.18-10.2; P = .023]).Limitations: Retrospective study and heterogeneity of treatments.Conclusion: The size and the number of S-ITM lesions confer an increased risk of relapse and the number of S-ITM an increased risk of specific-death in patients with cSCC presenting with S-ITM. These results provide new prognostic information and can be considered in the staging guidelines. ( J Am Acad Dermatol 2023;89:119-27.)
引用
收藏
页码:119 / 127
页数:9
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