Perspective Ferroptosis: A flexible constellation of related biochemical mechanisms

被引：130

作者：

Dixon, Scott J. ^{[1
]}

Pratt, Derek A. ^{[2
]}

机构：

[1] Stanford Univ, Dept Biol, Stanford, CA 94306 USA

[2] Univ Ottawa, Dept Chem & Biomol Sci, Ottawa, ON, Canada

来源：

MOLECULAR CELL | 2023年 / 83卷 / 07期

基金：

加拿大自然科学与工程研究理事会; 美国国家卫生研究院;

关键词：

POLYUNSATURATED FATTY-ACIDS; CELL-DEATH; LIPID-PEROXIDATION; PROMOTES FERROPTOSIS; OXIDATIVE STRESS; CANCER-CELLS; GPX4; METABOLISM; PROTECTS; DAMAGE;

D O I：

10.1016/j.molcel.2023.03.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is common to think about and depict biological processes as being governed by fixed pathways with spe-cific components interconnected by concrete positive and negative interactions. However, these models may fail to effectively capture the regulation of cell biological processes that are driven by chemical mecha-nisms that do not rely absolutely on specific metabolites or proteins. Here, we discuss how ferroptosis, a non-apoptotic cell death mechanism with emerging links to disease, may be best understood as a highly flexible mechanism that can be executed and regulated by many functionally related metabolites and proteins. The inherent plasticity of ferroptosis has implications for how to define and study this mechanism in healthy and diseased cells and organisms.

引用

页码：1030 / 1042

页数：13

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