Characterization, Antimicrobial and Anticancer Properties of Palladium Nanoparticles Biosynthesized Routed Through Bacillus sp

被引：2

作者：

Jayakumar, Tharani ^{[1
]}

Mani, Geetha ^{[1
]}

Dhayalan, Sangeetha ^{[1
]}

Sennimalai, Ramya ^{[2
,3
]}

Krishnamoorthy, Kavithaa ^{[4
]}

Govindasamy, Chandramohan ^{[5
]}

Al-Numair, Khalid S. ^{[5
]}

Alsaif, Mohammed A. ^{[5
]}

Cheon, Yong Pil ^{[6
]}

机构：

[1] Annamalai Univ, Dept Microbiol, Chidambaram 608002, Tamil Nadu, India

[2] Bharathiar Univ, Dept Zool, Coimbatore 641046, Tamil Nadu, India

[3] PSGR Krishnammal Coll Women, Coimbatore 641004, Tamil Nadu, India

[4] Hindhusthan Coll Arts & Sci, Coimbatore 641028, Tamil Nadu, India

[5] King Saud Univ, Coll Appl Med Sci, Dept Community Hlth Sci, POB 10219, Riyadh 11433, Saudi Arabia

[6] Sungshin Univ, Dept Biotechnol, Div Dev Biol & Physiol, Seoul 02844, South Korea

来源：

JOURNAL OF CLUSTER SCIENCE | 2023年 / 34卷 / 06期

关键词：

Bacterial secondary metabolites; Bacillus sp; Respiratory bacterial pathogens; Lung cancer; SILVER NANOPARTICLES; OXIDATIVE STRESS; GREEN SYNTHESIS; CELLS;

D O I：

10.1007/s10876-023-02435-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Bacterial secondary metabolites are the current focus of investigation as a potential solution to various drug resistance and other problems. Palladium nanoparticles produced by Bacillus sp are considered to be green, eco-friendly, cost-effective, and they also have antibacterial and anticancer capabilities which could be used in pharmaceuticals. Agar well screening has proven that the secondary metabolites of Bacillus sp (TAP 4) have antibacterial properties. Ultraviolet-visible (UV-Vis) spectroscopy was used to determine the synthesis of palladium nanoparticles. Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and X ray diffraction (XRD) were used to examine the morphological appearances, stability, and crystalline structure of palladium nanoparticles from the secondary metabolites of Bacillus sp. Using DCFH-DA, we determined the impact of secondary metabolites of synthesized nanoparticles on ROS levels and mitochondrial membrane potential (MMP) by two-fold serial dilution method. On A549 lung cancer cells, the cytotoxicity of synthesized secondary metabolites mediated palladium nanoparticles was measured using MTT assay to determine their anticancer activities. Our findings indicated that their secondary metabolites have a promising role as a first-line cancer drug. However, further research is required to entirely understand their mode of mechanistic action.

引用

页码：2919 / 2930

页数：12