ZSWIM1 Promotes the Proliferation and Metastasis of Lung Adenocarcinoma Cells through the STK38/MEKK2/ERK1/2 Axis

被引：2

作者：

Gao, Xuejuan ^{[1
,2
]}

Lian, Qionghua ^{[1
,2
]}

Guan, Baiye ^{[1
,2
]}

Liu, Qiu-Yu ^{[3
]}

Meng, Meng ^{[1
,2
]}

Chen, Yang ^{[1
,2
]}

Jin, Jingjie ^{[1
,2
]}

Li, Huihua ^{[1
,2
]}

Liu, Xiaohui ^{[1
,2
]}

Sun, Zhenghua ^{[1
,2
]}

Liu, Langxia ^{[1
,2
]}

He, Qing-Yu ^{[1
,2
]}

Zhang, Gong ^{[1
,2
]}

机构：

[1] Jinan Univ, MOE Key Lab Tumor Mol Biol, Guangzhou 510632, Peoples R China

[2] Jinan Univ, Guangdong Higher Educ Inst, Inst Life & Hlth Engn, Coll Life Sci & Technol,Key Lab Funct Protein Res, Guangzhou 510632, Peoples R China

[3] Zhengzhou Univ, Henan Prov Peoples Hosp, Peoples Hosp, Dept Pathol, Zhengzhou 450003, Peoples R China

来源：

JOURNAL OF PROTEOME RESEARCH | 2023年 / 22卷 / 04期

关键词：

ZSWIM1; STK38; ERK1; 2; proliferation; migration; lung adenocarcinoma; SIGNALING PATHWAY; INVOLVEMENT; ACTIVATION;

D O I：

10.1021/acs.jproteome.2c00412

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Investigating the functions of the proteins with no or less functional annotations is an important goal of the HPP (Human Proteome Project) Grand Project. In this study, we investigated the function of such a protein, ZSWIM1 (C20orf162), its gene located on chromosome 20. Its expression is upregulated in lung adenocarcinoma compared with the adjacent normal tissues and negatively correlated with the overall survival. Over-expressing ZSWIM1 markedly promotes the proliferation, migration, invasion as well as epithelial-to-mesenchymal transition in lung adenocarcinoma cells, while knocking down ZSWIM1 functions oppositely. The interactome of ZSWIM1 was identified by immunoprecipitation-mass spectrometry, and we verified the interaction of ZSWIM1 with the potential partner, STK38. ZSWIM1 antagonized the function of STK38. Mechanically, ZSWIM1 promoted the activation of MEKK2/ERK1/2 pathway through interacting with STK38, leading to the release of MEKK2. Taken together, ZSWIM1 can be annotated as an oncogene in lung adenocarcinoma, and the STK38/MEKK2/ERK1/2 axis mediates its promoting role in lung adenocarcinoma.

引用

页码：1080 / 1091

页数：12

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