FREQUENCY SYNCHRONIZATION REVEALS THAT SPIKE-WAVE DISCHARGES IN WAG/RIJ RATS ARE SIGNIFICANTLY NONLINEAR PHENOMENON

被引：0

作者：

Dolinina, Anastasiya Yu. ^{[1
,2
]}

Sysoeva, Marina V. ^{[1
,3
]}

Van Rijn, Clementina M. ^{[4
]}

Sysoev, Ilya V. ^{[1
,2
]}

机构：

[1] RAS, Saratov Branch, Kotelnikov Inst Radioengn & Elect, Zelyonaya St 38, Saratov 410019, Russia

[2] Saratov NG Chernyshevskii State Univ, Astrakhanskaya St 83, Saratov 410012, Russia

[3] Yuri Gagarin State Tech Univ Saratov, Politekhnicheskaya St 77, Saratov 410056, Russia

[4] Radboud Univ Nijmegen, Donders Ctr Cognit, Montessorilaan 3, NL-6525 HR Nijmegen, Netherlands

来源：

JOURNAL OF BIOLOGICAL SYSTEMS | 2024年 / 32卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

Spike-Wave Discharge; Time-Frequency Analysis; Skeleton; Frequency Dynamics; GRANGER CAUSALITY; ABSENCE EPILEPSY; MODEL; MECHANISMS; SEIZURES; DYNAMICS; STRAIN; BRAIN;

D O I：

10.1142/S0218339024500098

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this work, we studied the time-frequency dynamics of spike-wave discharges in rats with predisposition to absence epilepsy (WAG/Rij line) in two frequency ranges: 7-12Hz and 14-24Hz. The first and the second harmonics of the seizure main frequency lie in these ranges. Recordings of brain local field potentials of eight animals in eleven experiments of eight hour duration were analyzed. The method was based on the fast Fourier transform with a Hann's window, and skeletons were constructed based on the obtained spectrograms. Using the skeletons, a visual and automated numerical assessment of the main frequency evolution was performed. As a result of this analysis, it was shown that temporal dynamics of the main frequency in the range 14-24Hz follows the dynamics of the main frequency in the range 7-12Hz. Since during the baseline activity the main frequencies in two considered ranges were developing independently, our finding indicates that the discharge is a significantly nonlinear process.

引用

页码：239 / 250

页数：12

共 40 条

[1] Electroencephalographic differences between WAG/Rij and GAERS rat models of absence epilepsy [J].

Akman, Ozlem ;

Demiralp, Tamer ;

Ates, Nurbay ;

Onat, Filiz Yilmaz .

EPILEPSY RESEARCH, 2010, 89 (2-3) :185-193

[2] Indications of nonlinear deterministic and finite-dimensional structures in time series of brain electrical activity: Dependence on recording region and brain state [J].

Andrzejak, RG ;

Lehnertz, K ;

Mormann, F ;

Rieke, C ;

David, P ;

Elger, CE .

PHYSICAL REVIEW E, 2001, 64 (06) :8-061907

[3]

Avakyan G., 2017, Epilepsia and paroxyzmal conditions, V9, P6, DOI [10.17749/2077-8333.2017.9.2.006-019, DOI 10.17749/2077-8333.2017.9.2.006-019]

[4] Frequency Synchronization and Its Possible Role in Microworld Phenomena [J].

Blekhman, I. I. .

AUTOMATION AND REMOTE CONTROL, 2020, 81 (08) :1405-1412

[5] On self-synchronization and controlled synchronization [J].

Blekhman, II ;

Fradkov, AL ;

Nijmeijer, H ;

Pogromsky, AY .

SYSTEMS & CONTROL LETTERS, 1997, 31 (05) :299-305

[6]

Boccaletti S, 2018, Synchronization: from coupled systems to complex networks

[7] Some peculiarities of time-frequency dynamics of spike-wave discharges in humans and rats [J].

Bosnyakova, D. ;

Gabova, A. ;

Zharikova, A. ;

Gnezditski, V. ;

Kuznetsova, G. ;

van Luijtelaar, G. .

CLINICAL NEUROPHYSIOLOGY, 2007, 118 (08) :1736-1743

[8]

BURNS DA, 1992, J ROY SOC MED, V85, P37

[9] Genetic animal models for absence epilepsy: A review of the WAG/Rij strain of rats [J].

Coenen, AML ;

van Luijtelaar, ELJM .

BEHAVIOR GENETICS, 2003, 33 (06) :635-655

[10] The pilocarpine model of temporal lobe epilepsy [J].

Curia, Giulia ;

Longo, Daniela ;

Biagini, Giuseppe ;

Jones, Roland S. G. ;

Avoli, Massimo .

JOURNAL OF NEUROSCIENCE METHODS, 2008, 172 (02) :143-157

← 1 2 3 4 →