Relative Recovery of Non-Alcoholic Fatty Liver Disease (NAFLD) in Diet-Induced Obese Rats

被引:2
作者
Aboujassoum, Hamda M. [1 ]
Mohamed-Ali, Vidya [2 ,3 ]
Abraham, David [4 ]
Clapp, Lucie H. [5 ]
Al-Naemi, Hamda A. [1 ,6 ]
Ding, Qiurong
机构
[1] Qatar Univ, Lab Anim Res Ctr, POB 2713, Doha, Qatar
[2] Antidoping Lab Qatar, POB 2713,Sports City Rd, Doha, Qatar
[3] UCL, Ctr Metab & Inflammat, Div Med, Royal Free Campus,Rowland Hill St, London NW3 2PF, England
[4] UCL, Ctr Rheumatol & Connect Tissue Disorders, Div Med, Royal Free Campus,Rowland Hill St, London NW3 2PF, England
[5] UCL, Inst Cardiovasc Sci, Rayne Bldg,5 Univ St, London WC1E 6JF, England
[6] Qatar Univ, Dept Biol & Environm Sci, POB 2713, Doha, Qatar
关键词
cafeteria diet; obesity; metabolic syndrome; non-alcoholic fatty liver diseases; hepatic steatosis; DE-NOVO LIPOGENESIS; METABOLIC SYNDROME; CAFETERIA DIET; INSULIN-RESISTANCE; HIGH-CARBOHYDRATE; RISK; MANAGEMENT; DIAGNOSIS; FRUCTOSE; MODEL;
D O I
10.3390/nu16010115
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Consumption of a high-carbohydrate diet has a critical role in the induction of weight gain and obesity-related pathologies. This study tested the hypothesis that a carbohydrate-rich diet induces weight gain, ectopic fat deposition, associated metabolic risks and development of non-alcoholic fatty liver disease (NAFLD), which are partially reversible following carbohydrate reduction. Sprague Dawley (SD) rats were fed a carbohydrate-enriched cafeteria diet (CAF) or normal chow (NC) ad libitum for 16-18 weeks. In the reversible group (REV), the CAF was replaced with NC for a further 3 weeks (18-21 weeks). Animals fed the CAF diet showed significantly increased body weight compared to those fed NC, accompanied by abnormal changes in their systemic insulin and triglycerides, elevation of hepatic triglyceride and hepatic steatosis. In the REV group, when the CAF diet was stopped, a modest, non-significant weight loss was associated with improvement in systemic insulin and appearance of the liver, with lower gross fatty deposits and hepatic triglyceride. In conclusion, a carbohydrate-enriched diet led to many features of metabolic syndrome, including hyperinsulinemia, while a dietary reduction in this macronutrient, even for a short period, was able to restore normoinsulinemia, and reversed some of the obesity-related hepatic abnormalities, without significant weight loss.
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页数:13
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