A Review of the Role of Bioreactors for iPSCs-Based Tissue-Engineered Articular Cartilage

被引:6
|
作者
Reina-Mahecha, Alejandro [1 ]
Beers, Martine J. [2 ]
van der Veen, Hugo C. [2 ]
Zuhorn, Inge S. [1 ]
van Kooten, Theo G. [1 ]
Sharma, Prashant K. [1 ]
机构
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Biomed Engn, FB40,Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands
[2] Univ Med Ctr Groningen, Dept Orthoped, Groningen, Netherlands
关键词
Osteoarthritis; Bioreactors; Mechanical stimulation; Tissue engineering; iPSCs; MESENCHYMAL STEM-CELLS; BONE-MARROW; MECHANICAL STIMULATION; HYDROSTATIC-PRESSURE; ANIMAL RESEARCH; GENE-THERAPY; OSTEOARTHRITIS; CHONDROCYTES; REGENERATION; EXPRESSION;
D O I
10.1007/s13770-023-00573-6
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Background:Osteoarthritis (OA) is the most common degenerative joint disease without an ultimate treatment. In a search for novel approaches, tissue engineering (TE) has shown great potential to be an effective way for hyaline cartilage regeneration and repair in advanced stages of OA. Recently, induced pluripotent stem cells (iPSCs) have been appointed to be essential stem cells for degenerative disease treatment because they allow a personalized medicine approach. For clinical translation, bioreactors in combination with iPSCs-engineerd cartilage could match patients needs, serve as platform for large-scale patient specific cartilage production, and be a tool for patient OA modelling and drug screening. Furthermore, to minimize in vivo experiments and improve cell differentiation and cartilage extracellular matrix (ECM) deposition, TE combines existing approaches with bioreactors.Methods:This review summarizes the current understanding of bioreactors and the necessary parameters when they are intended for cartilage TE, focusing on the potential use of iPSCs.Results:Bioreactors intended for cartilage TE must resemble the joint cavity niche. However, recreating human synovial joints is not trivial because the interactions between various stimuli are not entirely understood.Conclusion:The use of mechanical and electrical stimulation to differentiate iPSCs, and maintain and test chondrocytes are key stimuli influencing hyaline cartilage homeostasis. Incorporating these stimuli to bioreactors can positively impact cartilage TE approaches and their possibility for posterior translation into the clinics.
引用
收藏
页码:1041 / 1052
页数:12
相关论文
共 50 条
  • [31] Biological aspects of tissue-engineered cartilage
    Hoshi, Kazuto
    Fujihara, Yuko
    Yamawaki, Takanori
    Harai, Motohiro
    Asawa, Yukiyo
    Hikita, Atsuhiko
    HISTOCHEMISTRY AND CELL BIOLOGY, 2018, 149 (04) : 375 - 381
  • [32] Facilitating In Vivo Articular Cartilage Repair by Tissue-Engineered Cartilage Grafts Produced From Auricular Chondrocytes
    Wong, Chin-Chean
    Chen, Chih-Hwa
    Chiu, Li-Hsuan
    Tsuang, Yang-Hwei
    Bai, Meng-Yi
    Chung, Ren-Jei
    Lin, Yun-Ho
    Hsieh, Fon-Jou
    Chen, You-Tzung
    Yang, Tsung-Lin
    AMERICAN JOURNAL OF SPORTS MEDICINE, 2018, 46 (03): : 713 - 727
  • [33] Internal support of tissue-engineered cartilage
    Arévalo-Silva, CA
    Eavey, RD
    Cao, YL
    Vacanti, M
    Weng, YL
    Vacanti, CA
    ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2000, 126 (12) : 1448 - 1452
  • [34] Glycogen storage in tissue-engineered cartilage
    Suits, Jocelyne M. T.
    Khan, Aasma A.
    Waldman, Stephen D.
    JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2008, 2 (06) : 340 - 346
  • [35] Compressive properties of tissue-engineered cartilage
    Horkay, F
    Horkayne-Szakaly, I
    Basser, PJ
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U579 - U580
  • [36] Biomechanical evaluation of suture-holding properties of native and tissue-engineered articular cartilage
    G. D. DuRaine
    B. Arzi
    J. K. Lee
    C. A. Lee
    D. J. Responte
    J. C. Hu
    K. A. Athanasiou
    Biomechanics and Modeling in Mechanobiology, 2015, 14 : 73 - 81
  • [37] Evaluating potential of tissue-engineered cryogels and chondrocyte derived exosomes in articular cartilage repair
    Nikhil, Aman
    Kumar, Ashok
    BIOTECHNOLOGY AND BIOENGINEERING, 2022, 119 (02) : 605 - 625
  • [38] Biomechanical issues of tissue-engineered constructs for articular cartilage regeneration: in vitro and in vivo approaches
    Cipollaro, Lucio
    Ciardulli, Maria Camilla
    Della Porta, Giovanna
    Peretti, Giuseppe M.
    Maffulli, Nicola
    BRITISH MEDICAL BULLETIN, 2019, 132 (01) : 53 - 80
  • [39] TISSUE-ENGINEERED HUMAN ARTICULAR CARTILAGE DEMONSTRATES INTENSE IMMUNOPOSITIVITY FOR COLLAGEN TYPE II
    Munirah, S.
    Aminuddin, B. S.
    Chua, K. H.
    Samsudin, O. C.
    Badrul, A. H. M. Y.
    Azmi, B.
    Fuzina, N. H.
    Ruszymah, B. H., I
    TROPICAL LIFE SCIENCES RESEARCH, 2006, 17 (01) : 9 - 18
  • [40] Biomechanical evaluation of suture-holding properties of native and tissue-engineered articular cartilage
    DuRaine, G. D.
    Arzi, B.
    Lee, J. K.
    Lee, C. A.
    Responte, D. J.
    Hu, J. C.
    Athanasiou, K. A.
    BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, 2015, 14 (01) : 73 - 81