A Review of the Role of Bioreactors for iPSCs-Based Tissue-Engineered Articular Cartilage

被引:6
|
作者
Reina-Mahecha, Alejandro [1 ]
Beers, Martine J. [2 ]
van der Veen, Hugo C. [2 ]
Zuhorn, Inge S. [1 ]
van Kooten, Theo G. [1 ]
Sharma, Prashant K. [1 ]
机构
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Biomed Engn, FB40,Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands
[2] Univ Med Ctr Groningen, Dept Orthoped, Groningen, Netherlands
关键词
Osteoarthritis; Bioreactors; Mechanical stimulation; Tissue engineering; iPSCs; MESENCHYMAL STEM-CELLS; BONE-MARROW; MECHANICAL STIMULATION; HYDROSTATIC-PRESSURE; ANIMAL RESEARCH; GENE-THERAPY; OSTEOARTHRITIS; CHONDROCYTES; REGENERATION; EXPRESSION;
D O I
10.1007/s13770-023-00573-6
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Background:Osteoarthritis (OA) is the most common degenerative joint disease without an ultimate treatment. In a search for novel approaches, tissue engineering (TE) has shown great potential to be an effective way for hyaline cartilage regeneration and repair in advanced stages of OA. Recently, induced pluripotent stem cells (iPSCs) have been appointed to be essential stem cells for degenerative disease treatment because they allow a personalized medicine approach. For clinical translation, bioreactors in combination with iPSCs-engineerd cartilage could match patients needs, serve as platform for large-scale patient specific cartilage production, and be a tool for patient OA modelling and drug screening. Furthermore, to minimize in vivo experiments and improve cell differentiation and cartilage extracellular matrix (ECM) deposition, TE combines existing approaches with bioreactors.Methods:This review summarizes the current understanding of bioreactors and the necessary parameters when they are intended for cartilage TE, focusing on the potential use of iPSCs.Results:Bioreactors intended for cartilage TE must resemble the joint cavity niche. However, recreating human synovial joints is not trivial because the interactions between various stimuli are not entirely understood.Conclusion:The use of mechanical and electrical stimulation to differentiate iPSCs, and maintain and test chondrocytes are key stimuli influencing hyaline cartilage homeostasis. Incorporating these stimuli to bioreactors can positively impact cartilage TE approaches and their possibility for posterior translation into the clinics.
引用
收藏
页码:1041 / 1052
页数:12
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