A Review of the Role of Bioreactors for iPSCs-Based Tissue-Engineered Articular Cartilage

被引:6
|
作者
Reina-Mahecha, Alejandro [1 ]
Beers, Martine J. [2 ]
van der Veen, Hugo C. [2 ]
Zuhorn, Inge S. [1 ]
van Kooten, Theo G. [1 ]
Sharma, Prashant K. [1 ]
机构
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Biomed Engn, FB40,Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands
[2] Univ Med Ctr Groningen, Dept Orthoped, Groningen, Netherlands
关键词
Osteoarthritis; Bioreactors; Mechanical stimulation; Tissue engineering; iPSCs; MESENCHYMAL STEM-CELLS; BONE-MARROW; MECHANICAL STIMULATION; HYDROSTATIC-PRESSURE; ANIMAL RESEARCH; GENE-THERAPY; OSTEOARTHRITIS; CHONDROCYTES; REGENERATION; EXPRESSION;
D O I
10.1007/s13770-023-00573-6
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Background:Osteoarthritis (OA) is the most common degenerative joint disease without an ultimate treatment. In a search for novel approaches, tissue engineering (TE) has shown great potential to be an effective way for hyaline cartilage regeneration and repair in advanced stages of OA. Recently, induced pluripotent stem cells (iPSCs) have been appointed to be essential stem cells for degenerative disease treatment because they allow a personalized medicine approach. For clinical translation, bioreactors in combination with iPSCs-engineerd cartilage could match patients needs, serve as platform for large-scale patient specific cartilage production, and be a tool for patient OA modelling and drug screening. Furthermore, to minimize in vivo experiments and improve cell differentiation and cartilage extracellular matrix (ECM) deposition, TE combines existing approaches with bioreactors.Methods:This review summarizes the current understanding of bioreactors and the necessary parameters when they are intended for cartilage TE, focusing on the potential use of iPSCs.Results:Bioreactors intended for cartilage TE must resemble the joint cavity niche. However, recreating human synovial joints is not trivial because the interactions between various stimuli are not entirely understood.Conclusion:The use of mechanical and electrical stimulation to differentiate iPSCs, and maintain and test chondrocytes are key stimuli influencing hyaline cartilage homeostasis. Incorporating these stimuli to bioreactors can positively impact cartilage TE approaches and their possibility for posterior translation into the clinics.
引用
收藏
页码:1041 / 1052
页数:12
相关论文
共 50 条
  • [11] Functional tissue-engineered microtissue derived from cartilage extracellular matrix for articular cartilage regeneration
    Yin, Heyong
    Wang, Yu
    Sun, Xun
    Cui, Ganghua
    Sun, Zhen
    Chen, Peng
    Xu, Yichi
    Yuan, Xueling
    Meng, Haoye
    Xu, Wenjing
    Wang, Aiyuan
    Guo, Quanyi
    Lu, Shibi
    Peng, Jiang
    ACTA BIOMATERIALIA, 2018, 77 : 127 - 141
  • [12] Tissue-engineered articular cartilage exhibits tension-compression nonlinearity reminiscent of the native cartilage
    Kelly, Terri-Ann N.
    Roach, Brendan L.
    Weidner, Zachary D.
    Mackenzie-Smith, Charles R.
    O'Connell, Grace D.
    Lima, Eric G.
    Stoker, Aaron M.
    Cook, James L.
    Ateshian, Gerard A.
    Hung, Clark T.
    JOURNAL OF BIOMECHANICS, 2013, 46 (11) : 1784 - 1791
  • [13] Regenerative Potential of Tissue-Engineered Nasal Chondrocytes in Goat Articular Cartilage Defects
    Mumme, Marcus
    Steinitz, Amir
    Nuss, Katja M.
    Klein, Karina
    Feliciano, Sandra
    Kronen, Peter
    Jakob, Marcel
    von Rechenberg, Brigitte
    Martin, Ivan
    Barbero, Andrea
    Pelttari, Karoliina
    TISSUE ENGINEERING PART A, 2016, 22 (21-22) : 1286 - +
  • [14] MRI evaluation of deformation fields and glycosaminoglycan concentrations in tissue-engineered articular cartilage
    Neu, C. P.
    Arastu, H.
    Curtiss, S.
    Reddi, A. H.
    TISSUE ENGINEERING PART A, 2008, 14 (05) : 758 - 758
  • [15] Adhesion of tissue-engineered cartilage to native cartilage
    Silverman, RP
    Bonasser, L
    Passaretti, D
    Randolph, MA
    Yaremchuk, MJ
    PLASTIC AND RECONSTRUCTIVE SURGERY, 2000, 105 (04) : 1393 - 1398
  • [16] Tissue-engineered polyethylene oxide/chitosan scaffolds as potential substitutes for articular cartilage
    Kuo, Yung-Chih
    Hsu, Ya-Ru
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2009, 91A (01) : 277 - 287
  • [17] A Guide for Using Mechanical Stimulation to Enhance Tissue-Engineered Articular Cartilage Properties
    Salinas, Evelia Y.
    Hu, Jerry C.
    Athanasiou, Kyriacos
    TISSUE ENGINEERING PART B-REVIEWS, 2018, 24 (05) : 345 - 358
  • [18] Effects of Temporal Hydrostatic Pressure on Tissue-Engineered Bovine Articular Cartilage Constructs
    Elder, Benjamin D.
    Athanasiou, Kyriacos A.
    TISSUE ENGINEERING PART A, 2009, 15 (05) : 1151 - 1158
  • [19] Strategies for Enhancing the Accumulation and Retention of Extracellular Matrix in Tissue-Engineered Cartilage Cultured in Bioreactors
    Shahin, Kifah
    Doran, Pauline M.
    PLOS ONE, 2011, 6 (08):
  • [20] Type I Collagen-Based Fibrous Capsule Enhances Integration of Tissue-Engineered Cartilage with Native Articular Cartilage
    Yang, Yueh-Hsun
    Ard, Mary B.
    Halper, Jaroslava T.
    Barabino, Gilda A.
    ANNALS OF BIOMEDICAL ENGINEERING, 2014, 42 (04) : 716 - 726