Association of the respiratory severity score with bronchopulmonary dysplasia-associated pulmonary hypertension in infants born extremely preterm

被引：0

作者：

Beer, Lindsey ^{[1
,2
]}

Rivera, Brian K. ^{[1
,3
]}

Jama, Waceys ^{[1
]}

Slaughter, Jonathan L. ^{[1
,2
,3
,4
]}

Backes, Carl H. ^{[1
,2
,3
,4
,5
]}

Conroy, Sara ^{[1
,6
,7
]}

Kielt, Matthew J. ^{[1
,2
,8
]}

机构：

[1] Nationwide Childrens Hosp, Ohio Perinatal Res Network, Columbus, OH 43215 USA

[2] Nationwide Childrens Hosp, Div Neonatol, Columbus, OH 43215 USA

[3] Nationwide Childrens Hosp, Abigail Wexner Res Inst, Ctr Perinatal Res, Columbus, OH USA

[4] Ohio State Univ, Coll Med, Dept Pediat, Columbus, OH USA

[5] Nationwide Childrens Hosp, Heart Ctr, Columbus, OH USA

[6] Ohio State Univ, Coll Med, Ctr Biostat, Dept Biomed Informat, Columbus, OH USA

[7] Nationwide Childrens Hosp, Abigail Wexner Res Inst, Biostat Resource, Columbus, OH USA

[8] Nationwide Childrens Hosp, Comprehens Ctr Bronchopulmonary Dysplasia, Columbus, OH 43215 USA

来源：

JOURNAL OF PERINATOLOGY | 2024年 / 44卷 / 02期

关键词：

AMERICAN-HEART-ASSOCIATION; ARTERY HYPERTENSION; PREMATURE-INFANTS; VASCULAR-DISEASE; WEIGHT; GUIDELINES; CHILDREN; RISK; MANAGEMENT; DIAGNOSIS;

D O I：

10.1038/s41372-023-01798-y

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To test the hypothesis that elevations in the respiratory severity score (RSS) are associated with increased probability of bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH).Study design: Retrospective cohort study of infants born extremely preterm admitted to a BPD center between 2010 and 2018. Echocardiograms obtained >= 36 weeks' post-menstrual age (PMA) were independently adjudicated by two blinded cardiologists to determine the presence/absence of BPD-PH. Multivariable logistic regression estimated the association between RSS and BPD-PH.Result: BPD-PH was observed in 68/223 (36%) of subjects. The median RSS at time of echocardiography was 3.04 (Range 0-18.3). A one-point increase in the RSS was associated with BPD-PH, aOR 1.3 (95% CI 1.2-1.4), after adjustment for gestational age and PMA at time of echocardiography.Conclusion: Elevations in the RSS were associated with a greater probability of BPD-PH. Prospective studies are needed to determine the validity and performance of RSS as a clinical susceptibility/risk biomarker for BPD-PH.

引用

页码：294 / 300

页数：7

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