Association of the respiratory severity score with bronchopulmonary dysplasia-associated pulmonary hypertension in infants born extremely preterm

被引：0
作者：
Beer, Lindsey [1 ,2 ]
Rivera, Brian K. [1 ,3 ]
Jama, Waceys [1 ]
Slaughter, Jonathan L. [1 ,2 ,3 ,4 ]
Backes, Carl H. [1 ,2 ,3 ,4 ,5 ]
Conroy, Sara [1 ,6 ,7 ]
Kielt, Matthew J. [1 ,2 ,8 ]
机构：
[1] Nationwide Childrens Hosp, Ohio Perinatal Res Network, Columbus, OH 43215 USA
[2] Nationwide Childrens Hosp, Div Neonatol, Columbus, OH 43215 USA
[3] Nationwide Childrens Hosp, Abigail Wexner Res Inst, Ctr Perinatal Res, Columbus, OH USA
[4] Ohio State Univ, Coll Med, Dept Pediat, Columbus, OH USA
[5] Nationwide Childrens Hosp, Heart Ctr, Columbus, OH USA
[6] Ohio State Univ, Coll Med, Ctr Biostat, Dept Biomed Informat, Columbus, OH USA
[7] Nationwide Childrens Hosp, Abigail Wexner Res Inst, Biostat Resource, Columbus, OH USA
[8] Nationwide Childrens Hosp, Comprehens Ctr Bronchopulmonary Dysplasia, Columbus, OH 43215 USA
来源：
JOURNAL OF PERINATOLOGY | 2024年 / 44卷 / 02期
关键词：
AMERICAN-HEART-ASSOCIATION; ARTERY HYPERTENSION; PREMATURE-INFANTS; VASCULAR-DISEASE; WEIGHT; GUIDELINES; CHILDREN; RISK; MANAGEMENT; DIAGNOSIS;
D O I：
10.1038/s41372-023-01798-y
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To test the hypothesis that elevations in the respiratory severity score (RSS) are associated with increased probability of bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH).Study design: Retrospective cohort study of infants born extremely preterm admitted to a BPD center between 2010 and 2018. Echocardiograms obtained >= 36 weeks' post-menstrual age (PMA) were independently adjudicated by two blinded cardiologists to determine the presence/absence of BPD-PH. Multivariable logistic regression estimated the association between RSS and BPD-PH.Result: BPD-PH was observed in 68/223 (36%) of subjects. The median RSS at time of echocardiography was 3.04 (Range 0-18.3). A one-point increase in the RSS was associated with BPD-PH, aOR 1.3 (95% CI 1.2-1.4), after adjustment for gestational age and PMA at time of echocardiography.Conclusion: Elevations in the RSS were associated with a greater probability of BPD-PH. Prospective studies are needed to determine the validity and performance of RSS as a clinical susceptibility/risk biomarker for BPD-PH.
引用
收藏
页码：294 / 300
页数：7
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