The association between frailty and osteoarthritis based on the NHANES and Mendelian randomization study

被引：7

作者：

Huang, Guoxin ^{[1
]}

Qian, Da

Liu, Ying ^{[1
]}

Qu, Gaojing ^{[1
]}

Qian, Yuanyuan ^{[2
]}

Pei, Bin ^{[1
]}

机构：

[1] Hubei Univ Med, Xiangyang 1 Peoples Hosp, Dept Evidence Based Med Ctr, Xiangyang, Peoples R China

[2] Soochow Univ, Changshu 1 Peoples Hosp, Dept Burn & Plast Surg Hand Surg, Changshu Hosp, Changshu, Peoples R China

来源：

ARCHIVES OF MEDICAL SCIENCE | 2023年 / 19卷 / 05期

关键词：

frailty; osteoarthritis; National Health and Nutrition Examination Survey; Mendelian randomization; HIP;

D O I：

10.5114/aoms/171270

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: The aim of the study was to examine the association between frailty and osteoarthritis. Methods: We conducted a cross-sectional study in the National Health and Nutrition Examination Survey, while logistic regression was used to explore the association of the two. Mendelian randomization (MR) study was used to explore the causal relationship between the two. Results: In the cross- sectional study, logistic regression analysis showed that odds ratio (OR) (95% CI) value was 1.07 (1.05, 1.08). In the MR study, the inverse-variance weighting (IVW) results showed OR (95% CI) value of 1.69 (1.01-2.83). Conclusions: There is both a correlation and a causal relationship between frailty and osteoarthritis, and frailty may be a potentially better response than age to osteoarthritis.

引用

页码：1545 / 1550

页数：6

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