Preparation of polysaccharide-based nanoparticles by chitosan and flaxseed gum polyelectrolyte complexation as carriers for bighead carp (Aristichthys nobilis) peptide delivery

被引：8

作者：

Zheng, Changliang ^{[1
,2
]}

Chen, Mengting ^{[1
]}

Chen, Yashu ^{[3
]}

Qu, Yinghong ^{[2
]}

Shi, Wenzheng ^{[2
]}

Shi, Liu ^{[1
]}

Qiao, Yu ^{[1
]}

Li, Xin ^{[1
]}

Guo, Xiaojia ^{[1
]}

Wang, Lan ^{[1
]}

Wu, Wenjin ^{[1
]}

机构：

[1] Hubei Acad Agr Sci, Inst Agroprod Proc & Nucl Agr Technol, Key Lab Agr Prod Cold Chain Logist, Minist Agr & Rural Affairs, Wuhan 430064, Peoples R China

[2] Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai 201306, Peoples R China

[3] Chinese Acad Agr Sci, Oil Crops Res Inst, Hubei Key Lab Lipid Chem & Nutr, Key Lab Oilseeds Proc,Minist Agr & Rural Affairs, Wuhan 430062, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2023年 / 249卷

关键词：

Chitosan; Flaxseed gum; Polyelectrolyte complexation; Bighead carp peptide; Control release; TRIPOLYPHOSPHATE NANOPARTICLES; BIOACTIVE PEPTIDES; ANTIOXIDANT; RELEASE; ENCAPSULATION; COACERVATION; BIOPOLYMER; FRACTION; PROTEIN; SYSTEM;

D O I：

10.1016/j.ijbiomac.2023.126121

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polysaccharide-based nanoparticles formed by the polyelectrolyte complexation between chitosan (CS) and flaxseed gum (FG) was developed in this work, and it was further used as a carrier for bighead carp peptide (BCP) delivery. The CS molecular weight (MW) of 50 kDa and CS/FG mass ratio of 1:2 at pH 3.5 were optimal conditions for the NP preparation, with the minimum particle size (similar to 155.1 nm) and the maximum BCP encapsulation efficiency (60.3 %). The BCP-loaded CS/FG NPs exhibited the smallest particle size (175.8 nm). Both CS/FG NPs and CS/FG-BCP NPs exhibited roughly uniform spherical shape. FT-IR spectra confirmed the existence of hydrogen bonds and electrostatic interactions in the nanoparticles. The BCP-loaded NPs displayed a higher thermal stability than BCP. Moreover, the release of BCP was controllable and dose-dependent, following a firstorder kinetics model. These findings suggested that our CS/FG NPs are a promising carrier for bioactive peptide delivery.

引用

页数：10