Differential diagnosis of suspected multiple sclerosis: an updated consensus approach

被引：65

作者：

Solomon, Andrew J. ^{[1
]}

Arrambide, Georgina ^{[2
]}

Brownlee, Wallace J. ^{[3
]}

Flanagan, Eoin P. ^{[4
,5
,6
]}

Amato, Maria Pia ^{[7
,8
]}

Amezcua, Lilyana ^{[9
]}

Banwell, Brenda L. ^{[10
,11
]}

Barkhof, Frederik ^{[12
,13
,14
]}

Corboy, John R. ^{[15
]}

Correale, Jorge ^{[16
,17
]}

Fujihara, Kazuo ^{[18
,19
]}

Graves, Jennifer ^{[20
]}

Harnegie, Mary Pat ^{[21
]}

Hemmer, Bernhard ^{[23
,24
]}

Lechner-Scott, Jeannette ^{[25
,26
]}

Marrie, Ruth Ann ^{[27
,28
]}

Newsome, Scott D. ^{[29
]}

Rocca, Maria A. ^{[30
]}

Royal III, Walter ^{[31
,32
]}

Waubant, Emmanuelle L. ^{[33
]}

Yamout, Bassem ^{[34
]}

Cohen, Jeffrey A. ^{[22
]}

机构：

[1] Univ Vermont, Univ Hlth Ctr, Dept Neurol Sci, Larner Coll Med, Burlington, VT 05401 USA

[2] Univ Autonoma Barcelona, Vall dHebron Hosp Univ, Vall dHebron Inst Recerca, Serv Neurol Neuroimmunol,Ctr Esclerosi Multiple Ca, Barcelona, Spain

[3] Natl Hosp Neurol & Neurosurg, Queen Sq, London, England

[4] Mayo Clin, Dept Neurol, Rochester, MN USA

[5] Mayo Clin, Ctr Multiple Sclerosis & Autoimmune Neurol, Rochester, MN USA

[6] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA

[7] Univ Florence, Dept NEUROFARBA, Florence, Italy

[8] IRCCS Fdn Don Carlo Gnocchi, Florence, Italy

[9] Univ Southern Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA USA

[10] Univ Penn, Dept Neurol, Div Child Neurol, Philadelphia, PA USA

[11] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA USA

[12] Vrije Univ, Dept Radiol & Nucl Med, Amsterdam UMC, Amsterdam, Netherlands

[13] UCL, Queen Sq Inst Neurol, London, England

[14] UCL, Ctr Med Image Comp, London, England

[15] Univ Colorado, Dept Neurol, Sch Med, Aurora, CO USA

[16] Fleni Inst Biol Chem & Phys Chem IQUIFIB, Dept Neurol, Buenos Aires, Argentina

[17] Univ Buenos Aires, Natl Council Sci & Tech Res, Buenos Aires, Argentina

[18] Fukushima Med Univ, Dept Multiple Sclerosis Therapeut, Sch Med, Koriyama, Japan

[19] Southern TOHOKU Res Inst Neurosci, Multiple Sclerosis & Neuromyelitis Opt Ctr, Koriyama, Japan

[20] Univ Calif San Diego, Dept Neurosci, San Diego, CA USA

[21] Cleveland Clin, Cleveland Clin Lib, Cleveland, OH USA

[22] Cleveland Clin, Mellen Ctr MS Treatment & Res, Neurol Inst, Cleveland, OH USA

[23] Tech Univ Munich, Med Fac, Dept Neurol, Klinikum Rechts Isar, Munich, Germany

[24] Munich Cluster Syst Neurol, Munich, Germany

[25] John Hunter Hosp, Dept Neurol, Newcastle, NSW, Australia

[26] Univ Newcastle, Hunter Med Res Inst Neurol, Newcastle, NSW, Australia

[27] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Dept Internal Med, Winnipeg, MB, Canada

[28] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Dept Community Hlth Sci, Winnipeg, MB, Canada

[29] Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD USA

[30] Univ Vita Salute San Raffaele, IRCCS San Raffaele Sci Inst, Div Neurosci, Neuroimaging Res Unit,Neurol Unit, Milan, Italy

[31] Morehouse Sch Med, Dept Neurobiol, Atlanta, GA USA

[32] Morehouse Sch Med, Neurosci Inst, Atlanta, GA USA

[33] Univ Calif San Francisco, Weill Inst Neurosci, San Francisco, CA USA

[34] Harley St Med Ctr, Neurol Inst, Abu Dhabi, U Arab Emirates

来源：

LANCET NEUROLOGY | 2023年 / 22卷 / 08期

关键词：

OLIGODENDROCYTE GLYCOPROTEIN ANTIBODIES; CEREBROSPINAL-FLUID ANALYSIS; NEUROMYELITIS-OPTICA; TRANSVERSE MYELITIS; SPECTRUM; MISDIAGNOSIS; NEURITIS; CRITERIA; MRI; MS;

D O I：

10.1016/S1474-4422(23)00148-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Accurate diagnosis of multiple sclerosis requires careful attention to its differential diagnosis-many disorders can mimic the clinical manifestations and paraclinical findings of this disease. A collaborative effort, organised by The International Advisory Committee on Clinical Trials in Multiple Sclerosis in 2008, provided diagnostic approaches to multiple sclerosis and identified clinical and paraclinical findings (so-called red flags) suggestive of alternative diagnoses. Since then, knowledge of disorders in the differential diagnosis of multiple sclerosis has expanded substantially. For example, CNS inflammatory disorders that present with syndromes overlapping with multiple sclerosis can increasingly be distinguished from multiple sclerosis with the aid of specific clinical, MRI, and laboratory findings; studies of people misdiagnosed with multiple sclerosis have also provided insights into clinical presentations for which extra caution is warranted. Considering these data, an update to the recommended diagnostic approaches to common clinical presentations and key clinical and paraclinical red flags is warranted to inform the contemporary clinical evaluation of patients with suspected multiple sclerosis.

引用

页码：750 / 768

页数：19

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