Diagnosis and Treatment of Obstructive Hypertrophic Cardiomyopathy

被引:2
作者
Todde, Gaetano [1 ]
Canciello, Grazia [1 ]
Borrelli, Felice [1 ]
Perillo, Errico Federico [1 ]
Esposito, Giovanni [1 ]
Lombardi, Raffaella [1 ]
Losi, Maria Angela [1 ]
机构
[1] Univ Naples Federico II, Dept Adv Biomed Sci, I-80138 Naples, Italy
关键词
hypertrophic cardiomyopathy; left ventricular outflow obstruction; systolic anterior motion; OUTFLOW TRACT OBSTRUCTION; MUSCULAR SUBAORTIC STENOSIS; SYSTOLIC ANTERIOR MOTION; DOUBLE-BLIND; VERAPAMIL; HCM; PROPRANOLOL; PREVALENCE; MAVACAMTEN; PREVENTION;
D O I
10.3390/cardiogenetics13020008
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Left ventricular outflow obstruction (LVOTO) and diastolic dysfunction are the main pathophysiological characteristics of hypertrophic cardiomyopathy (HCM)LVOTO, may be identified in more than half of HCM patients and represents an important determinant of symptoms and a predictor of worse prognosis. This review aims to clarify the LVOTO mechanism in, diagnosis of, and therapeutic strategies for patients with obstructive HCM.
引用
收藏
页码:75 / 91
页数:17
相关论文
共 49 条
  • [1] ADELMAN AG, 1970, BRIT HEART J, V32, P804
  • [2] Updated Meta-Analysis of Septal Alcohol Ablation Versus Myectomy for Hypertrophic Cardiomyopathy
    Agarwal, Shikhar
    Tuzcu, E. Murat
    Desai, Milind Y.
    Smedira, Nicholas
    Lever, Harry M.
    Lytle, Bruce W.
    Kapadia, Samir R.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 55 (08) : 823 - 834
  • [3] Alcohol Septal Ablation versus Septal Myectomy Treatment of Obstructive Hypertrophic Cardiomyopathy: A Systematic Review and Meta-Analysis
    Bytyci, Ibadete
    Nistri, Stefano
    Morner, Stellan
    Henein, Michael Y.
    [J]. JOURNAL OF CLINICAL MEDICINE, 2020, 9 (10) : 1 - 12
  • [4] Role of multimodality cardiac imaging in the management of patients with hypertrophic cardiomyopathy: an expert consensus of the European Association of Cardiovascular Imaging Endorsed by the Saudi Heart Association
    Cardim, Nuno
    Galderisi, Maurizio
    Edvardsen, Thor
    Plein, Sven
    Popescu, Bogdan A.
    D'Andrea, Antonello
    Bruder, Oliver
    Cosyns, Bernard
    Davin, Laurent
    Donal, Erwan
    Freitas, Antonio
    Habib, Gilbert
    Kitsiou, Anastasia
    Petersen, Steffen E.
    Schroeder, Stephen
    Lancellotti, Patrizio
    [J]. EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 2015, 16 (03) : 280 - +
  • [5] Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy
    Chuang, Chihyuan
    Collibee, Scott
    Ashcraft, Luke
    Wang, Wenyue
    Vander Wal, Mark
    Wang, Xiaolin
    Hwee, Darren T.
    Wu, Yangsong
    Wang, Jingying
    Chin, Eva R.
    Cremin, Peadar
    Zamora, Jeanelle
    Hartman, James
    Schaletzky, Julia
    Wehri, Eddie
    Robertson, Laura A.
    Malik, Fady, I
    Morgan, Bradley P.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (19) : 14142 - 14152
  • [6] AMELIORATION OF ANGINA PECTORIS IN IDIOPATHIC HYPERTROPHIC SUBAORTIC STENOSIS WITH BETA-ADRENERGIC BLOCKADE
    COHEN, LS
    BRAUNWALD, E
    [J]. CIRCULATION, 1967, 35 (05) : 847 - +
  • [7] POSTOPERATIVE AND LONG-TERM PROGNOSIS OF MYOTOMY MYOMECTOMY FOR OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY - INFLUENCE OF ASSOCIATED MITRAL-VALVE REPLACEMENT
    DELAHAYE, F
    JEGADEN, O
    DEGEVIGNEY, G
    GENOUD, JL
    PERINETTI, M
    MONTAGNA, P
    DELAYE, J
    MIKAELOFF, P
    [J]. EUROPEAN HEART JOURNAL, 1993, 14 (09) : 1229 - 1237
  • [8] Study design and rationale of VALOR-HCM : evaluation of mavacamten in adults with symptomatic obstructive hypertrophic cardiomyopathy who are eligible for septal reduction therapy
    Desai, Milind Y.
    Wolski, Kathy
    Owens, Anjali
    Naidu, Srihari S.
    Geske, Jeffrey B.
    Smedira, Nicholas G.
    Schaff, Hartzell
    Lampl, Kathy
    McErlean, Ellen
    Sewell, Christina
    Zhang, David
    Edelberg, Jay M.
    Sehnert, Amy J.
    Nissen, Steven E.
    [J]. AMERICAN HEART JOURNAL, 2021, 239 : 80 - 89
  • [9] DOI YL, 1983, EUR HEART J, V4, P838, DOI 10.1093/oxfordjournals.eurheartj.a061411
  • [10] Randomized Trial of Metoprolol in Patients With Obstructive Hypertrophic Cardiomyopathy
    Dybro, Anne M.
    Rasmussen, Torsten B.
    Nielsen, Roni R.
    Andersen, Mads J.
    Jensen, Morten K.
    Poulsen, Steen H.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2021, 78 (25) : 2505 - 2517