Rhodium-catalyzed enantioselective annulation of N-phenoxyacetamides with 1,3-dienes

被引：6

作者：

Yang, Hui ^{[1
]}

Yang, Zi-Qi ^{[1
]}

Zhang, Su-Zhen ^{[1
]}

Zhang, Wen-Wen ^{[1
]}

Gu, Qing ^{[1
]}

You, Shu-Li ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

SCIENCE CHINA-CHEMISTRY | 2023年 / 66卷 / 10期

基金：

中国国家自然科学基金;

关键词：

asymmetric catalysis; C-H functionalization; rhodium catalysis; chiral dihydrobenzofuran; C-H FUNCTIONALIZATION; ASYMMETRIC HYDROGENATION; BOND FUNCTIONALIZATION; ACTIVATION; RH; DERIVATIVES; BENZOFURAN; ALKYLATION; AMIDATION; COMPLEXES;

D O I：

10.1007/s11426-023-1637-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chiral dihydrobenzofuran is a valuable synthetic fragment in both medicinal and organic chemistry. Efficient rhodium(III)-catalyzed chemoselective and enantioselective C-H functionalization/[3+2] annulation of N-phenoxyacetamides with 1,3-dienes is reported. In the presence of 5 mol% CpRh complex, various chiral dihydrobenzofurans were synthesized in up to 79% yield and 98% ee. This reaction proceeds under mild conditions with excellent functional group compatibility.

引用

页码：2842 / 2846

页数：5

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