The effect of high oral loading dose of cholecalciferol in non-alcoholic fatty liver disease patients. A randomized placebo controlled trial

被引：4

作者：

Mohamed, Amal Ahmed ^{[1
]}

Halim, Ahmed Abdel ^{[2
]}

Mohamed, Sahar ^{[2
]}

Mahmoud, Seham Mohamed ^{[3
]}

Eldemiry, Eman Mohamed Bahgat ^{[4
]}

Mohamed, Rasha Sobh ^{[5
]}

Shaheen, Mahmoud Maamoun ^{[5
]}

Naguib, Gina G. ^{[6
]}

Muharram, Nashwa M. ^{[7
]}

Khalil, Mona G. ^{[8
]}

Saed, Salma ^{[9
]}

Ibrahim, Randa ^{[10
]}

Seif, Ahmed Salah ^{[11
]}

Kamal, Noha ^{[12
]}

Nasraldin, Karima ^{[13
]}

Abdelrahman, Ali Elsaid ^{[14
]}

El Borolossy, Radwa ^{[15
]}

机构：

[1] Natl Hepatol & Trop Med Res Inst, Dept Biochem & Mol Biol, Cairo, Egypt

[2] Natl Hepatol & Trop Med Res Inst, Trop Med Dept, Cairo, Egypt

[3] El Sahel Teaching Hosp, Trop Med Dept, Cairo, Egypt

[4] Cairo Univ Hosp, Fac Pharm, Clin Pharmacol, Cairo, Egypt

[5] Cairo Univ, Fac Med, Internal Med Dept, Cairo, Egypt

[6] Ain Shams Univ, Fac Med, Dept Internal Med, Cairo, Egypt

[7] Menoufia Univ, Fac Med, Med Biochem & Mol Biol, Menoufia, Egypt

[8] Modern Univ Technol & Informat, Fac Pharm, Pharmacol & Toxicol Dept, Cairo, Egypt

[9] Cairo Univ, Fac Med, Clin & Chem Pathol Dept, Cairo, Egypt

[10] Nutr Inst Cairo, Clin & Chem Pathol Dept, Cairo, Egypt

[11] Shebeen El Kom Teaching Hosp, Trop Med Hepatol & Gastroenterol Dept, Menoufia, Egypt

[12] Gulf Med Univ GMU, Theodor Bilharz Res Inst TBRI, Clin Pathol Dept, Minist Sci Res & Higher Educ, Cairo, Egypt

[13] Modern Sci & Arts Univ, Fac Biotechnol, Cairo, Egypt

[14] Natl Hepatol & Trop Med Res Inst, Diagnost & Intervent Radiol, Cairo, Egypt

[15] Ain Shams Univ, Dept Clin Pharm, Fac Pharm, Cairo, Egypt

来源：

FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷

关键词：

non-alcoholic fatty liver; Cholecalciferol; Steatosis; lipid profile; hsCRP; HEPATIC STELLATE CELLS; VITAMIN-D LEVELS; 25-HYDROXYVITAMIN D-3; AMERICAN ASSOCIATION; MANAGEMENT; STEATOHEPATITIS; CHILDREN; TRANSPLANTATION; EXPRESSION; HISTOLOGY;

D O I：

10.3389/fphar.2023.1149967

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background and Aim: Non-alcoholic fatty liver (NAFLD) is one of the most common progressive metabolic disorders worldwide. There are increasing scientific interests nowadays for the association between vitamin D status and Non-alcoholic fatty liver. Earlier studies have revealed that vitamin D deficiency is highly prevalent in Non-alcoholic fatty liver patients that contributes to poor outcomes. Hence, the present study aimed to assess the efficacy and safety of oral cholecalciferol on Non-alcoholic fatty liver patients.Subjects and Methods: This study was conducted on 140 patients that were randomized either to group 1 that received the standard conventional therapy in addition to placebo or group 2 that received the standard conventional therapy in addition to cholecalciferol during the 4 months study period.Results: At the end of the study group 2 revealed significant decrease (p < 0.05) in the mean serum level of TG, LDL-C, TC, hsCRP as compared to their baseline results and group 1 results. Additionally, a significant improvement in the serum levels of ALT (p = 0.001) was seen in group 2 at the end of the study when compared to group 1. Whereas group 1 did not show any change in these parameters when compared to group 2 and their baseline results.Conclusion: Cholecalciferol was shown to have beneficial effects on serum ALT levels, hsCRP levels and lipid profile of NAFLD patients.

引用

页数：8

共 42 条

[11]

Benedict M, 2017, WORLD J HEPATOL, V9, P715, DOI 10.4254/wjh.v9.i16.715

[12] The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association [J].

Chalasani, Naga ;

Younossi, Zobair ;

Lavine, Joel E. ;

Diehl, Anna Mae ;

Brunt, Elizabeth M. ;

Cusi, Kenneth ;

Charlton, Michael ;

Sanyal, Arun J. .

HEPATOLOGY, 2012, 55 (06) :2005-2023

[13] Frequency and Outcomes of Liver Transplantation for Nonalcoholic Steatohepatitis in the United States [J].

Charlton, Michael R. ;

Burns, Justin M. ;

Pedersen, Rachel A. ;

Watt, Kymberly D. ;

Heimbach, Julie K. ;

Dierkhising, Ross A. .

GASTROENTEROLOGY, 2011, 141 (04) :1249-1253

[14] Modern approach to the clinical management of non-alcoholic fatty liver disease [J].

Del Ben, Maria ;

Polimeni, Licia ;

Baratta, Francesco ;

Pastori, Daniele ;

Loffredo, Lorenzo ;

Angelico, Francesco .

WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (26) :8341-8350

[15] A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response [J].

Ding, Ning ;

Yu, Ruth T. ;

Subramaniam, Nanthakumar ;

Sherman, Mara H. ;

Wilson, Caroline ;

Rao, Renuka ;

Leblanc, Mathias ;

Coulter, Sally ;

He, Mingxiao ;

Scott, Christopher ;

Lau, Sue L. ;

Atkins, Annette R. ;

Barish, Grant D. ;

Gunton, Jenny E. ;

Liddle, Christopher ;

Downes, Michael ;

Evans, Ronald M. .

CELL, 2013, 153 (03) :601-613

[16]

EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1016/j.jhep.2015.11.004, 10.1159/000443344, 10.1007/s00125-016-3902-y]

[17] Meta-analysis: vitamin D and non-alcoholic fatty liver disease [J].

Eliades, M. ;

Spyrou, E. ;

Agrawal, N. ;

Lazo, M. ;

Brancati, F. L. ;

Potter, J. J. ;

Koteish, A. A. ;

Clark, J. M. ;

Guallar, E. ;

Hernaez, R. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2013, 38 (03) :246-254

[18]

Finelli Carmine, 2012, J Gastrointestin Liver Dis, V21, P205

[19]

Foroughi Mehdi, 2016, Iran J Nurs Midwifery Res, V21, P100, DOI 10.4103/1735-9066.174759

[20] AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY COMPREHENSIVE CLINICAL PRACTICE GUIDELINES FOR MEDICAL CARE OF PATIENTS WITH OBESITY [J].

Garvey, W. Timothy ;

Mechanick, Jeffrey I. ;

Brett, Elise M. ;

Garber, Alan J. ;

Hurley, Daniel L. ;

Jastreboff, Ania M. ;

Nadolsky, Karl ;

Pessah-Pollack, Rachel ;

Plodkowski, Raymond .

ENDOCRINE PRACTICE, 2016, 22 (07) :842-884

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