Global motion processing in infants' visual cortex and the emergence of autism

被引:4
作者
Hardiansyah, Irzam [1 ,2 ]
Nystroem, Par [3 ]
Taylor, Mark J. J. [4 ]
Bolte, Sven [1 ,2 ,5 ]
Ronald, Angelica [6 ]
Falck-Ytter, Terje [1 ,2 ,7 ,8 ]
机构
[1] Karolinska Inst, Ctr Neurodev Disorders Karolinska Inst KIND, Dept Womens & Childrens Hlth, Stockholm, Sweden
[2] Stockholm Hlth Care Serv, Stockholm, Sweden
[3] Uppsala Univ, Dept Psychol, Uppsala Child & Baby Lab, Uppsala, Sweden
[4] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
[5] Curtin Univ, Curtin Sch Allied Hlth, Curtin Autism Res Grp, Perth, Australia
[6] Birkbeck Univ London, Ctr Brain & Cognit Dev, Dept Psychol Sci, London, England
[7] Uppsala Univ, Dept Psychol, Dev & Neurodivers Lab, Uppsala, Sweden
[8] Swedish Coll Adv Study, Uppsala, Sweden
关键词
BIOLOGICAL MOTION; SPECTRUM DISORDER; BRAIN; PERCEPTION; FORM; COHERENCE; POPULATION; SEVERITY; TODDLERS; TRAITS;
D O I
10.1038/s42003-023-04707-3
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Autism is a heritable and common neurodevelopmental condition, with behavioural symptoms typically emerging around age 2 to 3 years. Differences in basic perceptual processes have been documented in autistic children and adults. Specifically, data from many experiments suggest links between autism and alterations in global visual motion processing (i.e., when individual motion information is integrated to perceive an overall coherent pattern). Yet, no study has investigated whether a distinctive organization of global motion processing precede the emergence of autistic symptoms in early childhood. Here, using a validated infant electroencephalography (EEG) experimental paradigm, we first establish the normative activation profiles for global form, global motion, local form, and local motion in the visual cortex based on data from two samples of 5-month-old infants (total n = 473). Further, in a sample of 5-month-olds at elevated likelihood of autism (n = 52), we show that a different topographical organization of global motion processing is associated with autistic symptoms in toddlerhood. These findings advance the understanding of neural organization of infants' basic visual processing, and its role in the development of autism. EEG data from nearly 500 five month old infants shows that a different topographical organization of global motion processing is associated with autistic symptoms in toddlerhood.
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页数:10
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