Prognostic Significance of Serum Albumin Level and Albumin-Based Mono- and Combination Biomarkers in Patients with Hepatocellular Carcinoma

被引：24

作者：

Jeng, Long-Bin ^{[1
,2
,3
]}

Chan, Wen-Ling ^{[4
,5
]}

Teng, Chiao-Fang ^{[1
,6
,7
,8
]}

机构：

[1] China Med Univ Hosp, Organ Transplantat Ctr, Taichung 404, Taiwan

[2] China Med Univ Hosp, Dept Surg, Taichung 404, Taiwan

[3] China Med Univ Hosp, Cell Therapy Ctr, Taichung 404, Taiwan

[4] Asia Univ, Dept Bioinformat & Med Engn, Taichung 413, Taiwan

[5] China Med Univ Hosp, Epigenome Res Ctr, Taichung 404, Taiwan

[6] China Med Univ, Grad Inst Biomed Sci, Taichung 404, Taiwan

[7] China Med Univ, Program Canc Biol & Drug Dev, Taichung 404, Taiwan

[8] China Med Univ, Res Ctr Canc Biol, Taichung 404, Taiwan

来源：

CANCERS | 2023年 / 15卷 / 04期

关键词：

hepatocellular carcinoma; albumin; prognostic significance; mono-biomarker; combination biomarker; ALKALINE PHOSPHATASE RATIO; CHILD-TURCOTTE-PUGH; BILIRUBIN GRADE; LIVER RESECTION; TRANSARTERIAL CHEMOEMBOLIZATION; RADIOFREQUENCY ABLATION; ALBUMIN/GLOBULIN RATIO; CURATIVE RESECTION; PREDICTS PROGNOSIS; GLYCATED ALBUMIN;

D O I：

10.3390/cancers15041005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Simple Summary This review provides a comprehensive summary of the literature published thus far to highlight the prognostic significance of serum albumin (ALB) level and various ALB-based mono- and combination biomarkers in predicting the prognosis of patients with hepatocellular carcinoma (HCC) treated with different therapies. Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer. Although many surgical and nonsurgical therapeutic options have been established for treating HCC, the overall prognosis for HCC patients receiving different treatment modalities remains inadequate, which causes HCC to remain among the most life-threatening human cancers worldwide. Therefore, it is vitally important and urgently needed to develop valuable and independent prognostic biomarkers for the early prediction of poor prognosis in HCC patients, allowing more time for more timely and appropriate treatment to improve the survival of patients. As the most abundant protein in plasma, human serum albumin (ALB) is predominantly expressed by the liver and exhibits a wide variety of essential biological functions. It has been well recognized that serum ALB level is a significant independent biomarker for a broad spectrum of human diseases including cancer. Moreover, ALB has been commonly used as a potent biomaterial and therapeutic agent in clinical settings for the treatment of various human diseases. This review provides a comprehensive summary of the evidence from the up-to-date published literature to underscore the prognostic significance of serum ALB level and various ALB-based mono- and combination biomarkers in the prediction of the prognosis of HCC patients after treatment with different surgical, locoregional, and systemic therapies.

引用

页数：23

共 153 条

[1] Post-operative albumin-bilirubin grade predicts long-term outcomes among Child-Pugh grade A patients with hepatocellular carcinoma after curative resection [J].